Distribution models of recirculating lymphocytes

Linear time-invariant, linear time-variant, and linear time-delay models are compared to a more accurate nonlinear model for the distribution of recirculating lymphocytes to various relevant organs of the immune process. The models are based on various degrees of approximation to the complex nonNewtonian tubule flow and tissue diffusion phenomena. From the measured data, it is apparent that the basic premise of cel-population conservation is not valid within the organs measured. In other words, counts are lost due to nonrecirculation and removal, natural death, and migration to organs not measured. The analysis does successfully decouple the recirculating (passive) lymphocyte dynamics from the dynamic response (and active migration) which is due to antigenic (alien substance) stimulation.