Dynamic models and solutions for evaluating ventilation, perfusion and mass transfer in the lung. I. The models

A dynamic model of ventilation, perfusion, and mass transfer in the lung is developed. A simple basic model is extended to permit description and prediction of dynamic performance in the presence of ventilation/perfusion (V/Q) inhomogeneity through the lung, serial deadspace, transport lags, and the dynamic effects of changing the inspired partial pressures of gases of differing solubilities (the third-gas effect). The clinical applicability of the model is discussed.