Kidney Modeling: Status and Perspectives

Author

Thomas, S. Randall ; Layton, Anita T. ; Layton, Harold E. ; Moore, Leon C.

Author_Institution

Lab. of Comput. Methods, Univ. of Evry-Val d´´Essonne, Evry, France

Volume

94

Issue

4

fYear

2006

fDate

4/1/2006 12:00:00 AM

Firstpage

740

Lastpage

752

Abstract

Mathematical models have played an essential role in elucidating various functions of the kidney, including the mechanism by which the avian and mammalian kidney can produce a urine that is more concentrated than blood plasma, quasi-isosmotic reabsorption along the proximal tubule, and the control and regulation of glomerular filtration by the myogenic and tubuloglomerular feedback mechanisms. This review includes a brief description of relevant renal physiology, a summary of the contributions of mathematical models at various levels and describes our recent work toward the Renal Physiome.

Keywords

biomedical electrodes; biomedical engineering; blood; kidney; physiological models; blood plasma; computational biology; glomerular filtration; kidney physiology; multiscale systems biology; myogenic feedback mechanism; proximal tubule; quasi-isosmotic reabsorption; tubuloglomerular feedback mechanism; Anatomy; Biological system modeling; Blood vessels; Databases; Feedback; Filtration; Mathematical model; Physiology; Plasmas; Systems biology; Computational biology; database; kidney physiology; markup language; mathematical modeling; multi-scale systems biology; physiome;

fLanguage

English

Journal_Title

Proceedings of the IEEE

Publisher

ieee

ISSN

0018-9219

Type

jour

DOI

10.1109/JPROC.2006.871770

Filename

1618633