Urethral Sphincter EMG as Event Detector for Neurogenic Detrusor Overactivity

The aim of this study was to investigate the feasibility of using external urethral sphincter electromyogram (EMG) (EUS_EMG) to detect the onset of detrusor contractions in patients with both neurogenic detrusor overactivity (NDO) and detrusor sphincter dyssynergia (DSD). Detrusor pressure (P_det) and EUS_EMG was recorded in 23 neurogenic patients during slow artificial bladder filling. The time delay between the onset of EUS_EMG detrusor contraction and the onset of activity was calculated together with the detrusor pressure increase related to this delay. Of 23 patients enrolled, 12 patients showed both NDO and DSD. Of these 12 patients, 10 had a strong correlation between detrusor pressure and EUS_EMG . One patient in this group was excluded due to a storage pressure above 30 cmH₂O . Two detection methods were applied on the remaining 9 patients. Method 1 was a root mean square (RMS)-integrator with simple thresholding. This approach had a good sensitivity but also a poor specificity (many false-positive detections). Detection method 2 included a kurtosis-based scaling function, which was multiplied to a similar RMS-integrator as used in method 1. Onset detection occurred before P_det exceeded 18 cmH₂O with both methods. However, method 1 resulted in 14.1plusmn12.8 false-positive detections during one bladder filling.P_det at onset detection was on average 1.0plusmn1.1 cmH₂O higher with detection method 2 but the number of false-positives was reduced by 95.8%. This paper demonstrates the feasibility of using EUS_EMG to estimate the onset of a detrusor contraction in selected patients.