Three Dimensional Motion Control System of Ferromagnetic Particles for Magnetically Targeted Drug Delivery Systems

Author

Mishima, Fumihito ; Takeda, Shin-Ichi ; Izumi, Yoshinobu ; Nishijima, Shigehiro

Author_Institution

Div. of Sustainable Energy & Environ. Eng., Osaka Univ.

Volume

16

Issue

2

fYear

2006

fDate

6/1/2006 12:00:00 AM

Firstpage

1539

Lastpage

1542

Abstract

The development of a 3-dimensional (3-D) navigation system of ferromagnetic particles in a flow system was performed. In order to improve the practice of using externally-applied magnetic fields for targeting the magnetic particles to a circumscribed body region, we tested the feasibility of a novel 3-D navigation system, made by applying a strong external (magnetic) field through a GdBaCuO bulk superconductor. A 3-D theoretical model is proposed and used in order to evaluate the efficiency of the navigation/retention of magnetic particles in the flow system. Furthermore, an experimental model system was made and the efficiency of a prototype system was examined. Comparisons of experimental and the corresponding calculation results were made to examine the theoretical model system

Keywords

barium compounds; biomagnetism; drug delivery systems; ferromagnetic materials; gadolinium compounds; magnetic field effects; superconducting magnets; 3D motion control system; GdBaCuO; GdBaCuO bulk superconductor; circumscribed body region; externally-applied magnetic fields; feasibility; ferromagnetic particles; flow system; magnetically targeted drug delivery systems; model system; novel 3D navigation system; prototype system; retention; Blood flow; Cancer; Humans; Magnetic fields; Magnetic particles; Micromagnetics; Motion control; Navigation; Superconducting magnets; Targeted drug delivery; Bulk superconductor; drug delivery system; ferromagnetic particle; magnetic targeting;

fLanguage

English

Journal_Title

Applied Superconductivity, IEEE Transactions on

Publisher

ieee

ISSN

1051-8223

Type

jour

DOI

10.1109/TASC.2005.869666

Filename

1643148