Ultrasonic cardiac pacing in the porcine model

Author

Towe, Bruce C. ; Rho, Raymond

Author_Institution

Dept. of Bioeng., Arizona State Univ., Tempe, AZ, USA

Volume

53

Issue

7

fYear

2006

fDate

7/1/2006 12:00:00 AM

Firstpage

1446

Lastpage

1448

Abstract

Periodic pulses of intense ultrasound energy at 70 kHz with 5-ms duration at 3 MPa SPL applied to the exposed pig myocardium at physiologic rhythms were observed to produce cardiac pacing. Ten animals were successfully paced at pulse width and energy conditions above a certain threshold. Sigmoid strength-duration curves characterizing ultrasound´s effectiveness in pacing were observed to resemble those of electrical stimulation. We suggest that bioelectrical stimulatory effects of ultrasound on the heart are a radiation pressure effect and a manifestation of the known myocyte sensitivity to stretch.

Keywords

bioelectric phenomena; biomedical ultrasonics; cardiology; muscle; radiation pressure; 5 ms; 70 kHz; bioelectrical stimulatory effects; electrical stimulation; exposed pig myocardium; heart; myocyte stretch sensitivity; porcine model; radiation pressure effect; sigmoid strength-duration curves; ultrasonic cardiac pacing; Acoustic pulses; Acoustic waves; Animals; Attenuation; Bioelectric phenomena; Frequency; Heart; Myocardium; Rhythm; Ultrasonic imaging; Radiation pressure stimulation; ultrasonic pacing; ultrasound bioelectric stimulation; Animals; Cardiac Pacing, Artificial; Equipment Design; Equipment Failure Analysis; Feasibility Studies; Heart Conduction System; Heart Rate; Models, Animal; Pacemaker, Artificial; Swine; Ultrasonic Therapy;

fLanguage

English

Journal_Title

Biomedical Engineering, IEEE Transactions on

Publisher

ieee

ISSN

0018-9294

Type

jour

DOI

10.1109/TBME.2006.875715

Filename

1643417