Cell response to nano-islands produced by polymer demixing: a brief review

Author

Dalby, M.J. ; Pasqui, D. ; Affrossman, S.

Author_Institution

Centre for Cell Eng., Univ. of Glasgow, UK

Volume

151

Issue

2

fYear

2004

fDate

4/1/2004 12:00:00 AM

Firstpage

53

Lastpage

61

Abstract

This review looks at the present literature available regarding cell response to nano-islands produced by nanotopography. Polymer demixing is a chemical method of fabricating large areas of nanotopography quickly and cheaply, making it ideal for cell testing and thus allowing it to be one of the first well-researched methods in cell engineering. The review shows that cells respond strongly to the islands (cell types observed include endothelial cells, fibroblasts, osteoblasts, leucocytes and platelets). Such changes include differences in adhesion, growth, gene expression and morphology.

Keywords

adhesion; biomedical materials; cellular biophysics; island structure; nanostructured materials; nanotechnology; polymer blends; polymer films; polymer structure; reviews; surface topography; tissue engineering; cell adhesion; cell engineering; cell growth; cell morphology; cell response; cell testing; endothelial cells; fibroblasts; gene expression; leucocytes; nano-islands; nanotopography; osteoblasts; platelets; polymer demixing; review; tissue engineering;

fLanguage

English

Journal_Title

Nanobiotechnology, IEE Proceedings -

Publisher

iet

ISSN

1478-1581

Type

jour

DOI

10.1049/ip-nbt:20040534

Filename

1301801