بررسي نقش پرتودرماني و شيمي درماني توام در درمان تومورهاي سلول سنگفرش سر و گردن

Study of the Role of Combined Radiotherapy & Chemotherapy in Treatment of Squamous Cell tumors of Head and Neck

Introduction: Squamous cell carcinoma is the most common tumor of head and neck. According to clinical stage of disease, radiotherapy and/or surgeries (are) used for treatment of these tumos. Although improvement of treatment results has been reported with chemoradiotherapy , still some controversy exists about the benefit of adding chemotherapy. This study compares chemoradiotherapy vs_ radiotherapy alone. Materials and methods: One hundred and fifty five patients with squamous cell carcinoma of head and neck were categorized into two groups randomly . The first group was designed to receive conventional fractionation radiation therapy (90 Patients) , ranging from 50 to 70 Gy (5fractions per week and 2 Gy per fraction) and the other group was planned to get combined chemoradiotherapy (65 patients) Chemotherapy regimen consisted of Cisplatin (100mg/m^2) and 5,f-u (750mg/m^2), given 3 weeks concurrent or after radiotherapy . For statistical analysis Fischer exact test and independent T-test were used. Results: Initial response was seen in 69.4% following radiotherapy and 85.7% afther chemoradiation (p=0.031). Recurrence (Locoregional or distant) was seen in 46.7% and 26.2% of patients in radiotherapy and chemotherapy group , respectively. Mean time for recurrence afther treatment was 8.58 and 7.17 months in 2 groups , respectively. Conclusion: Addition of chemotherapy to radiotherapy causes decrease in recurrence and increase in initial response rate in squamous cell cancers of head and neck.