تاثير مصرف مكمل كلسيم بر سطح ليپيدها، ليپوپروتيين ها و آپوليپوپروتيين هاي سرم در زنان سالم 30-18 ساله

The Effect of Supplementary Calcium on Serum Lipids, Lipoproteins and Apolipoproteins in Healthy Adult Women Aged 18-30 Years

Introduction: Several authors have noted that oral calcium treatment was associated with a change in serum lipids and reduce the risk of cardiovascular disease. In present sutdy, we determined the effect of supplementary calcium on serum total cholesterol. TG, HDLc, LDLc, LDLc/ HDLc, Apo Al, Apo B and Apo All Apo B profile in young healthy adult women. Methods: 53 volunteers were divided into two groups randomly, the treatment group received 1000 mg/day calcium (four doses of 625 mgs calcium carbonate) for one complete menstrual period and the control group received placebo (dextrose). Total cholesterol, TG and HDLc was determined enzymatically, Apo Al and Apo B was determined immunoturbidimetrically. Results: There were no correlation between any of the studied variables and calcium intake from food, calcium supplement did not change correlation coefficient of LDLc with HDLc and Apo Al with Apo B. Compared to placebo, calcium carbonate decreased serum Apo B concentration (13.7 mg/dl , p< 0.01) and incrdased Apo All Apo B (0.32 unit , P< 0.05) and TG (15.75mg/dl, p<0.05) but the changes in other variables were not significant . Conclusion: These results suggest that calcium supplement increase serum TG and ApoAll Apo B but decrease Apo B. it seems that calcium supplementation may be useful for people who receive less calcium than recommended dietary allowance.