بررسي وضعيت تجويز آنتي‌بيوتيكها در بيمارستانهاي استان قم، سال 1397

Investigation on the States of Antibiotics Prescription in Hospitals in Qom, Iran, during 2019

زمينه و هدف: مصرف غيرمنطقي آنتي‌بيوتيك‌ها به افزايش مقاومت دارويي منجر مي‌شود. سيستم شيميايي درماني آناتوميك / دز مشخص روزانه (ATC/DDD: Anatomical Therapeutic Chemical/Defined Daily Dose) ابزاري براي نظارت بر استفاده و تحقيق در زمينه بهبود كيفيت مصرف داروها و مقايسه آمار مصرف دارو در سطح بين‌الملل و سطوح ديگر است. مطالعه حاضر با هدف تعيين وضعيت تجويز آنتي‌بيوتيك در بيمارستان‌هاي شهر قم انجام شده است. روش بررسي: اين مطالعه مقطعي روي 1200 پرونده بيماران با روش نمونه‌گيري چندمرحله‌اي در سال 1397 انجام شد. براي جمع‌آوري داده از پرسش‌نامه محقق‌ساخته شامل اطلاعات دموگرافيك و آنتي‌بيوتيك‌هاي مصرفي بيماران و سيستم ATC/DDD بر اساس شاخص DDD/100bed−days استفاده شد. اطلاعات با استفاده از نرم‌افزار SPSS ورژن 20، آمار توصيفي و آزمون تحليل واريانس تجزيه‌وتحليل شد. يافته‌ها: نتايج نشان مي‌دهد ميزان آنتي‌بيوتيك‌هاي تجويزشده با فصل بستري بيماران ارتباط معني‌داري نداشت (5/0

Background and Objectives: Irrational use of antibiotics can lead to increased drug resistance. The Anatomical Therapeutic Chemical/ Defined Daily Dose (ATC/DDD) system is a tool to monitor medication use, evaluate the improvements in drug consumption quality, and make comparisons between international and other levels in this regard. This study aimed to determine the status of antibiotic prescription in hospitals in Qom, Iran. Methods: This cross-sectional study was performed on 1200 medical records of the patients using a multi-stage sampling method in 2019. The data were collected through a researcher-made questionnaire to seek demographic information and antibiotics used by patients, as well as ATC/DDD based on the DDD/100 bed-days index. Furthermore, the data were analyzed in SPSS software (version 20) through descriptive statistics and analysis of variance. Results: The results showed no significant relationship between the number of prescribed antibiotics and the hospitalization season (P>0.05). The majority of the antibiotics were injectable (93.5%) prescribed by surgical specialists (50.70%). Gynecology and Children's hospitals obtained the highest (18.4%) and the least (12.4%) level of antibiotic prescription, respectively. The daily recommended doses for every 100 days of bed rest for the most common antibiotics were Amikacin (21.81), Ceftriaxone (33. 62), Ampicillin (19. 34), Meropenem (6.10), and Vancomycin (11.28). Conclusion: The results show that Amikacin, Ceftriaxone, Ampicillin, Meropenem, and Vancomycin were the most common antibiotics used in the present study accounting for more than 70% of the total antibiotics administered. The DDD/100 bed-days of the most commonly used antibiotics were higher than those reported by the World Health Organization.