ارزيابي حافظه فضايي در زنان مبتلا به سندرم تخمدان پلي كيستيك

Evaluation of Spatial Memory in Women with Polycystic Ovary Syndrome

سندرم تخمدان پلي كيستيك، يك اختلال شايع اندوكريني در زنان سنين باروري است. اين سندرم ممكن است با تاثير بر عملكرد شناختي، حافظه فضايي زنان مبتلا را مختل كند، لذا مطالعه حاضر با هدف ارزيابي حافظه فضايي در زنان مبتلا به سندرم تخمدان پلي كيستيك انجام شد. روش كار اين مطالعه توصيفي همبستگي در سال1392 با مشاركت 50 زن مبتلا به سندرم تخمدان پلي كيستيك و 50 زن غيرمبتلا به اين سندرم از بين زنان مراجعه كننده به كلينيك هاي تخصصي زنان و مامايي شهر تبريز انجام شد. جهت تشخيص سندروم پلي كيستيك از معيار PCO و جهت بررسي حافظه فضايي از آزمون كامپيوتري Spatial Working Memory براي هر فرد استفاده شد. سپس نتايج نمره حافظه فضايي دو گروه در نرم افزار SPSS21 با استفاده از آزمون هاي تي مستقل، كي دو و همبستگي پيرسون مورد تجزيه تحليل و مقايسه قرار گرفتند. ميزان p كمتر از 0/05معني دار در نظر گرفته شد. ينتيجه گيري بيماران مبتلا به سندرم تخمدان پلي كيستيك حافطه فضايي بهتري داشتند، اما چون اين قابليت از يك فرآيند پاتولوژيك منشا مي گيرد، مبين بهتر شدن كلي عملكرد شناختي نمي باشد، بنابراين پايش همه جانبه اين بيماران و احتمال ايجاد عوارض بيماري ضرورت پيدا مي كند.

Polycystic ovary syndrome is a common endocrine disorder in women of reproductive age. This syndrome may affect cognitive function and impair spatial memory. Therefore, this study was performed with aim to evaluate spatial memory in women with polycystic ovary syndrome. Methods This correlation descriptive study was performed in 2013 on 50 women with polycystic syndrome and 50 women without polycystic syndrome who were selected among those referring to specialized obstetrics and gynecology clinics. PCO criterion was used to diagnose polycystic ovary syndrome and Computer Spatial Working Memory Test was used to assess spatial memory. Then the score of spatial memory of the two groups were analyzed by SPSS software (version 21) and independent t-test, Chi-square and Pearson correlation test. p < 0.05 was considered statistically significant. Results Mean scores of spatial memory test in case and control groups were 0.52±0.88± 0.39±06 and, respectively. The difference in cognitive performance between the case and control groups was statistically significant (P <0.0001) and women with this syndrome had better performance than the control group. Also, spatial memory scores were significantly correlated with age (p = 0.002), but not significantly correlated with education level (p = 0.99) and body mass index (p = 0.38). Conclusion Patients with polycystic ovary syndrome had better spatial memory, but since this capability originates from a pathological process, it does not imply an overall improvement in cognitive function, so, comprehensive follow up of these patients and possible complications of the disease may be necessary.