كليدواژه :
Acute hepatitis B , Prostaglandin El , حاد B هپاتيت , ميزوپروستول , E1 پروستاگلاندين , Misoprostol
چكيده لاتين :
Background: Therapeutic measures for acute hepatitis B patients are mainly conservative and the most prognostic factors are natural course of the disease and host immune system effectiveness. Recently, the use of PG compounds for acceleration of recovery and improvement has been favored. Therefore, this study performed to determine the effectiveness of misoprostol (PGE analogoue) on acute hepatitis B.
Materials and methods: This study was a randomized controlled clinical trial with observation & interview technique. 30 patients with acute hepatitis B (i.e. serum HBsAg & Anti HBc IgM positive) with total bilirubin >l0mg% and negative Anti HCV, were selected. Patients were divided in two matched groups (based on Bilirubin, Transaminases, PT, PTT levels and also age). Case group received misoprostol 200 Gamag/gid for 14 days and controls received placebo daily for 14 days. The level of above mentioned variables were measured before & after intervention. Thereafter, statistical analysis was performed based on x^2 method and t-test P value<0.05 was considered significant.
Results:
differences between two groups was obvious after 14 days of initiating the treatment, so that at the end of second week of treatment, levels of Bil, SGPT, PTT and at the end of third week, amount of all mentioned variables except SGOT, were lower in case group than controls. In fourth week, decreasing in Bit, SGPT, ALP, PTT levels in case group were meaningful yet, and finally at the end of fifth week, this trend was constant.
Conclusion: Using Misoprostol in acute hepatitis B accelerates the trend of recovery and the Ievels of Bit and liver enzymes return to normal state.
