تعيين ميزان شيوع توكسوپلاسموز در بيماريهاي بدخيم با روش ايمونوفلورسانس غير مستقيم

The Assessment of Toxoplasmosis in the Sera of the Patients with Malignancy, through Indirect Immunoflourescent Method

Background and Objectives: Toxopalsmosis is a common zoonotic infection throughout the world. In the congenital from, pathogenic agent is transmitted to the fetus through the maternal placenta. Acquired infection is due to ingestion of the oncysts, which are cxfected by cats or transmitted through the contaminated meat. Congenital infection can lead to fetal death, pathological changes of CNS or the eye diseases. The acquired form of the disease is often without sign and symptom, or characterized by general lethargy, swelling of lymphatic nodes and chorioretinitis. In the immunocompromised patients and in the patients with malignancy or tissue implants as well as AIDS, lethal and acute infections take place. The purpose of this study, is the investigation for determining the rate of anti-toxoplasma gondii antibody in the sent of patients with malignancy, referred to the Gazi Hospital of Tabriz. Materials and Methods: In this study, a total number of 10(1 blood samples from (he patients with malignancy were collected and tested by indirect immunollurescent antibody method. Results: Prevalence of anti - toxopalsma antibody in patients with malignancy by the titration of 1:20 was found equale to 48%. The highest infection rate was seen in 61-70 years age group with 66.6 percent and the least rate was seen in the above 70 years age group with 14.21%. The highest rat of infection was observed among students and persons with unemployed jobs (61.5% and 59.1;`(, respectively) and the lowest rate was found among government employees (28.6%). A high rate of infection was seen among villagers (514%). The most prevalent antibody titration was in the rate of 1:100 (in 16 subjects) and the least of this titer was 1:20() (in 5 subjects). The titration of 1:800 was noticed in 4 patients from 61-70 years old age groupe. Conclusion: According to the high positive cases observed in these patients, there should he some regular screen programs to recognize chronic infections, and serial titration of antibodies in these patients should he done. Also, these patients should he treated with antitoxoplasmosis regimens.