مقايسه اثر ايمونوگلوبولين وريدي با دوز بالا با ايمونوگلوبولين وريدي با دوز پايين در بيماران مبتلا به سندرم گيلن باره حاد

Introduction:Acute inflammatory demyelinating peripheral neuropathy (Guillain-Barre-Syndrome) is by far the most common cause of immune-mediated peripheral nerve disease in children and with the neardisappearance ofpol iomyelitis, is responsible for the great majority of cases ofacute flaccid paralysis.Several controlled studies have done with corticosteroids, plasma pheresis and IVIG in pediatric patients.1VIG treatment can be done in two types oftreatment:I- High dose that means I gr/kglday for 2 days.2- Low dose that means 400mg/kglday for 5 days. Several studies in another countries have shown fasterrate of recovery inpatients who received total dose of IVIG in 2 days as opposed to 5 days. Material& methods: Because wehave notanystudy aboutthistwotypesof treatment in IRAN we decided to comparis on this two types of lVlGtreatment.So the patients that referred to Mofid children hospital for weakness and wediagnosed GBS(with history, physical examination, laboratories and EMG-NCV)aredividedintwo groups:1-High dose JVlGtreatment(experimentalgroup). 2-Low dose I V IG treatment(control group) Then the results evaluated. Findings:Our findings included that in high dose IVIG therapy we have faster rate of recovery and the Hospital stay is shorter than low dose IVIG-therapy. conclusion: in this type of treatment"because the patients cure faster", so complications are decreased in them. In the group of high dose IVIG therapy, lower and upper extremities weakness decreased in time. We did not receive anyrelationshipbetween sideetfects of drugs and the type of treatment. The relationship between high dose IVIG therapy and drug side effects was not significant.