برريس پتانسيل برانگيخته چشمي در بيماران مبتلا به نارسايي مزمن كليه و افراد با سابقه پيوند كليه

COMPARISON OF VISUAL EVOKED POTENTIAL (VEP) IN CHRONIC RENAL FAILURE AND TRANSPLANTED PATIENTS

Background and Objectives: In patients with chronic renal failure , delayed visual evoked potential (VEP) in addition to peripheral neuropathy is reported. In this study delayed visual evoked potential (VEP) was tested in chronic renal failure (CRF) patients on hemodialysis and those with renal transplantion. Materials and Methods: A total of thiry three patients in two groups were selected for VEP test. Group I consisted of 17 patients with CRF on hemodialysis (aged 19-60 years) and Group II included 16 transplantated patients (aged 19-57 years). We studied pattern shift VEP (PSVEP) with 34 checks after ruling out diabetes and ophthalmologic examination. P10D wave latency and amplitude were compared between two groups with studentʹs t-Test. Results: VEP abnormality was seen in 35% of hemodialysed patients, while such abnormality was not observed in 16 transplanted patients. Mean P100 wave latency with 34 checks in group I was 110-±9.95ms and in group II it was 1035.28 ms and this difference was significant (p<0.05). Ploo wave amplitude in group I was 6.91iv and in group II it was 9.4µv, however this difference was not significant (p>0.05). There was no significant relationship between VEP and hypertension, creatinine, PTH, duration of hemodialysis and transplantation (p>0.05). Conclusions: Delayed neural conduction in visual pathway is seen in patients with chronic renal failure, that can be improved after successful renal transplantation. Etiologic factors associated with abnormality might be circulating toxins or demyelination.