سلنيوم در بيماران مبتلا به طاسي منطقه اي : يك مطالعه مورد-شاهد

Selenium in patients with alopecia areata : A case-control study

Background: Autoimmune mechanisms are involved in the etiology of alopecia areata. It is also shown that selenium has some effects on regulation of auto immune mechanisms. Objective: To compare the plasma level of selenium between those with and without alopecia areata. Patients and Methods: In this case-control study. 29 patients with alopecia areata referred to Rani hospital in Tehran, and 29 persons without this disease were selected consequently. Plasma level of selenium was determined and compared between the groups.Results: The mean age of cases was female. The mean plasma selenium level in cases was significantly lower than what was observed in controls (62.1 ± 13.3 g/L vs. 88.3± 13.2 g 1 L, P<0.0005). Conclusion: This study indicated that mean plasma selenium level in patients with alopecia areata was lower than those without this disorder. It is recommended to evaluate the effects of adding selenium to dietary regimen of patients with alopecia areata.