مرکز منطقه ای اطلاع رساني علوم و فناوري - ارزيابي حساسيت بارورفلكس كاروتيدي در بيماران ندكر بعد از انفاركتوس ميوكارد

چكيده لاتين :

Background and Objectives: Reports are available which suggest depression of carotid baroreflex in myocardial infarcted (MI) patients. These patients are more subject to sudden death. The aim of the work presented here was to investigate carotid baroreflex sensitivity in male patients after myocardial infarction. Thus, in this study we examined relation between decrease in baroreflex sensitivity (BRS) and duration of cardiac cycle in male MI patients. Materials and Methods: The study was performed on 15 infarcted male patients in the range of 40 - 70 years with the first cardiac attack and the same number of age matched healthy persons without any cardiac or pulmonary diseases The study was performed in both supine and seated positions. In order to estimate carotid baroreflex Neck Suction Device (Eckberg model) was used and electrocardiogram was recorded continuously. Intensity of stimulation and duration of stimulation were - 30 mm Hg and 30 seconds respectively. Results: Duration of basic cardiac cycle in normal group in supine and seated positions was 0.8616+-0.13 SD seconds and 0.8619+-0.141 SD seconds respectively that increased to 0.9529+-0.12 SD seconds and 0.9436+-0.9436 SD seconds after stimulation(p<0.001). Duration of basic cardiac cycle in patient group in supine and seated positions was 0.8717+-0.127 SD seconds and 0.8215+-0.11 SD seconds respectively that increased to 0.9124+-0.153 SD seconds and 0.8767+-0.15 SD seconds after stimulation(p<0.05). When duration of basic cardiac cycle in supine and seated positions in patients was compared to healthy group, a difference of 0.0511+-0.011 SD (pO.OOl) in supine position and 0.032+-0.011 SD (pO.OOl) in seated position was observed. Baroreflex sensitivity significantly increased with age (r=0.736; pO.OOl for control group, r= 0.66; p<0.05 for patient group) in both the groups and the differences were statistically significant. Adaptation in patients group was less compared to control group (r= 0.9, pO.OOl for control group and r=0.673, p<0.01 for patient group). Conclusion: This clinical study suggest that analysis ofbaroreflex sensitivity in patients after MI can be important for prognosis.