كليدواژه :
تاكسول , :دي ترپنوييدها , منابع طبيعي , درخت سرخدار
چكيده لاتين :
Taxol, a diterpenoid secondary product of the yew species, has been recognized one of the best anticancer drugs to have emerged in the last 15 years. In this study we have measured the taxol content in various parts of the Taxus baccata L. grown on two natural population (Noor and Gorgan) in Iran at different sampling dates and evaluated effect of environmental factors on taxol levels of the yew tree. Our results indicated that needles and roots contain the highest quantity of taxol in proportion to the other parts of tree (from 0.0285 to 0.055 and 0.023 to 0.047% of dry wt, respectively), the lower average yield were found in the bark and twigs, and the lowest average yield was associated with the branches {from 0.0013 to 0.005% of dry wt.) These results also indicated that the content of taxol in needles, twigs and bark in both Gorgan and Noor natural populations in September was higher than June and december. Levels of taxol in needles, branches and roots in the native yew of Noor were higher than those of Gorgan. The levels were equal in twigs and reverse in bark. These results demonstrated that environmental factors are effective on taxol content in various parts of yew, and also suggest that foliage from yew trees growing in Iran may provide a renewable source for taxol production.
