اثر موضعي تركيب كلم و سفيده تخم مرغ بر ترميم زخم سوختگي در موش صحرايي

The Effect of Compound of Brassica Oleracea Land Egg-white on

Purpose: The present study was designed to investigate the effect of compound of Brassica Oleracea L. and egg-white on burn wound (type 2) healing in Rat. Methods and Material: 50 female rats were studied through dividing them to 5 groups of 10 rats. After general anesthesia with ketamin and xylazin (ip), an area of the back of rats was burned with red-hot 50 Rials coin and similar grade II burns were created. Control group received no medication. In the second group , the surface of wounds were covered daily with silver sulphadiazine. In the third group, the surface of wounds were covered daily with compound of cabbage extract and egg-white. In the fourth group, the surface of wounds were covered daily with compound of cabbage powder and egg-white and in the fifth group, the surface of wounds were covered daily with compound of fresh cabbage and egg-white. Rats were killed by ether at the end of 1,2,3 and 4 weeks and samples were taken from the wound region and were histologically assessed. Then the samples were coloured with Hematoxillin and Eosin and studied quantitatively, Results: Results showed that after 4 weeks the healing of burn wounds in the group receiving cabbage extract and egg-white was faster and better than other groups. The wound healing in silver sulphadiazin group and cabbage powder group were similar. There were no significant differences between these groups with cabbage extract and egg-white group. Conclusion: Administration of topical cabbage extract and egg-white once a day in second degree burn wounds enhances the healing. Nearly similar results were observed in the silver sulphadiazin group compared with cabbage extract and egg-white group.