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Erythema Multiforme

Erythema multiforme is a skin condition considered to be a hypersensitivity reaction to infections or drugs. It consists of a polymorphous eruption of macules, papules, and characteristic "target" lesions that are symmetrically scattered with a tendency to the distal extremities. There is minimal mucosal involvement. Management involves treating the presented infections or withdrawing the contributory drug. Mild cases resolve without any complications and do not necessitate treatment. Recurrent cases have been prevented with continuous acyclovir. Patients who have no response to acyclovir may respond to valacyclovir or famciclovir, which have better oral bioavailability and more suitable dosing. Patients with recurrent erythema multiforme despite suppressive antiviral therapy should be referred to a dermatologist for additional treatment.