تغيير ميزان كورتيزول ، سيتوكين ها IL-1A ، TGF-B ، TNF-A ، IFN-A,Y ، و ايمونوگلوبولين ها طي روزه داري اسلامي

Evaluation of Serum Levels of IL-a, TGF-(beta), TNF-(alpha), IFN-(alpha), IFN-(gamma), Cortisol and Immunoglobulins in Islamic Ramadan Fasting.

introduction: This research aimed determining the levels of cortisol, immunoglobulins and major serum cytokines, following Ramadan fasting, as immune response indexes. Materials and Methods: For this before and after Ramadan fasting study, twenty-five students residing at the dormitory of the Tehran University of Medical Sciences were selected. All cytokines levels (IL-1(alpha), TGF-(beta), TNF-(alpha), IFN-(alpha), IFN-(gamma)) were determined by the ELISA method, Immoglobulines were determined by the Radial Immunodiffusion (SRID) technique and cortisol levels were measured by EIA too. Results: While IFN-y a showed a considerable increase after Ramadan fasting (P<0.01), IFN-(alpha) and TNF-(alpha) had decreased (P>= 0.5 and <0.02 respectively). Serum level of TGF-(beta) increased but not significantly (P>0.3); cortisol also increased after one month of fasting (P<0.05). Serum IL-1a had a non-significant decrease (P >= 0.5). Although IgG & IgM levels showed no significant increase, IgA levels showed significant decrease [P<0.5]. Conclusion: Our data revealed that Ramadan fasting increased IFN-y, while decreasing TNF-a and IgA levels; ramadan fasting can probably increase T-Cell function, lower the inflammatory appreance rate and affect immunoglubulin production.