ارزيابي تداخل اثر تزريق نالتروكسان در ناحيه خلفي هيپوكمپ بر اثرات كورتيكوسترون بر روند تثبيت و به خاطرآوري حافظه در مدل يادگيري احترازي غير فعال در موش صحرايي

Interaction ofIntrahippocampal Injection of Naltheroxone and Corticosterone on Consolidation and Retreival Memory Processes in Passive Avoidance Task in Rat

Background and Objectives Previous studies suggested that the role ofcorticosterone on memory process probably is mediated by opiate system in Dorsal Hippocampus (DH). The aim of this study was to test whether there is any interaction between glucocorticoids and opiate system on memory consolidtaion and retrieval in passive avoidance learning task. Material and Methods: In this experimental study 120 male Wistar rats (250-300 gr) surgically implanted bilaterally with cannulae aimed at the DH were trained in passive anoidnace learning (PAL) task. Two days after training, retention test was done. Naltoroxe (10 or 20 ug/ul,ʹ perside) were injected bilaterally into DH following immediately after training by IP injection of corticostrone (I mglkg) or 30 min before of IP injection of corticostrone (I mglkg) in retrieval test. Results: The data indicated that injection of corticostrone immediatly after training of injected 30 min before of retrieval test enhanced and impaired memory consolidation and retrieval respectively (p