فراواني شاخص هاي استرس اكسيداتيو به دنبال ساكشن لوله داخل ناي در بيماران جراحي پيوند عروق كرونر بستري در بيمارستان قلب جماران تهران

The Frequency of Oxidative Stress Indexes after Endotracheal Suction in CABG Patients which Hospitalized in Jamaran Heart Hospital of Tehran

Background and Objectives: Some nursing and medicine activities may increase the production of free radicals in patients. Therefore, this study was performed to determine the effect of suction with a tube located inside of the trachea on the amount of oxidative stress indexes in CABG patients. Matrial and Methods: This clinical study was performed on 35 patients which were under coroner vascular graft surgery. Blood samples were collected 3 times (before, immediatery and 15 minutes after suction) and then, the amounts of glutathione and the activity of glutathione peroxidase were measured. Results: Results of this study showed that both glutathione and glutathione peroxidase activity are significantly decreased both in immediately and 15 minutes after suction comparing to before suction (p<0.001). Conclusions: Suction is a free radical producing process which causes some changes in activities of anti-oxidants. The defect of anti-oxidants related defense of body causes oxidative stress. Therefore, further studies are needed to find out a way to overcom this problem. Key words: Endotracheal Suction, Glutathione (GSH), Glutathione Peroxidas (GSH-P)