ارزيابي عملكرد سيستم اكولوموتور در بيماران مبتلا به پاركينسون ايديوپاتيك

Oculomotor Function in Idiopathic Parkinsonian Patients

Background: Parkinson could be regards the most prevalent degenerative disorder in the central nervous system. In addition to neuromuscular disorders, some degree of oculomotor dysfunction may be observed in these patients. The assessment of oculomotor system function may provide a viewpoint about the balance status of Parkinsonian patients and cold be regard as an appropriate tool for the extent of movement disorders. The purpose of this study was the evaluation of oculomotor system in patients with idiopathic Parkinsonʹs disease. Certainly, better understanding of mechanisms involved in this disorder, may help in designing rehabilitation programs and quality of life increment in these patients. Methods: In an analytic cross-sectional study, 30 patients (M: 18, F: 12) with idiopathic Parkinsonʹs disease and 30 (M: 20, F: 10) normal subjects, aged 35-70 years, were evaluated. Gain and phase of smooth pursuit eye movements (during horizontal and vertical situations) were recorded in 0.2 Hz velocity for all participants. Independent T and Man-Whitney U tests (when the data distributions were not normal) were used for the comparison of mean gain and phase of responses between groups. Data analysis was carried out by SPSS 1 5. Results: The average of gain, except for horizontal right eye condition, in normal subjects was significantly higher than patients with Parkinsonʹs disease (P < 0.05). Additionally, the average of phase, except for horizontal right eye condition, in patients with Parkinsonʹs disease was significantly increased compared to normal subjects (P <0.01). Conclusion: Serious oculomotor system dysfunction, both in horizontal and vertical situations, in idiopathic Parkinsonian patients may representative of dopaminergic control decrement in these patients.