مقايسه عملكرد عصاره هيدروالكلي ‌گلرنگ و گردو در مقابله با ديابت قندي نوع اول

Comparison of hydroalcoholic extract function of safflower and walnut against type 1 diabetes mellitus

Medicinal plants are rich in natural antioxidants and are thus employed as traditional medicines to treat many diseases. Walnut and safflower have been used in Iranian traditional medicines - as therapeutics for treatment of diabetes mellitus. 24 male rats, weighting 180 - 220 g, were randomly allocated to four groups with six rats per group. First group, nondiabetic rats; second group, diabetic rats; third group, diabetic rats treated with hydroalcoholic extract of safflower petals (200 mgkglBʹW) and fourth group, diabetic rats treated with hydroalcoholic extract of walnut leaves (200 mgkglBʹW}. At the beginning of tests and at the end of 2th and 6th weeks of experimental period, the blood sugar, HbAlc and insulin levels were measured. SPSS software was used for statistical data analysis. The results indicated significant difference in blood sugar and insulin levels in the treated diabetic groups compared with the other diabetic group (P<0.05). These results show that the hydroalcoholic extracts of safflower and walnut are effective in treatment of diabetes. It seems that these effects are related to flavonoides and their antioxidant effect. Further biochemical and pharmacological investigations should be carried out to elucidate the mechanism of action in detail.