گزارش چهار مورد پانكراتيت ارثي

Hereditary pancreatitis: Presentation of four cases

Hereditary pancreatitis (HP)1 is a rare autosomal dominant disorder with recurrent attacks of acute pancreatitis and frequent progression to chronic pancreatitis. Recently, mutations in the human cationic trypsinogen (TG-I) have been associated with HP. Three potential markers for inherited pancreatitis have been identified: (PRSS1, SPINK1,TATI).The disease is characterized by recurrent episodes of pancreatitis and frequent presence of calcified stones and an increased cumulative risk of pancreatic cancer in elderly patients with HP.The diagnosis of hereditary pancreatitis is based upon radiographic testing in the appropriate clinical setting.This study is a presentation of four cases of hereditary pancreatitis from one family. Conservative treatment is advised in acute phase of pancreatitis. Prescribing of antioxidants (such as vitamin C and E), low fat diet and endoscopic sphinctrotomy (ES) and surgery may be useful as therapeutics or preventive measures.