ارتباط بين سطح سرمي كروم با ميزان مالون دي آلدهيد سرمي در افراد مبتلا به ديابت نوع دو

The relationship between serum level of chromium and serum malondialdehyde in patients with type II diabetes

Background and aim: Several studies indicate that there might be relations between the serum levels of chromium and risk factors of diabetes. However, in the majority of these studies the interaction between the serum levels of chromium and the status of body antioxidants has been neglected and the focus has just been given to the role of chromium in the prevention of insulin resistance. The present study has been designed with the purpose of investigating the relation between the serum levels of chromium and the serum malondialdehyde in patients with type 2 diabetes. Methods: The subjects under investigation consisted of 30 patients (15 females, 15 males) aged 30-60, with type 2 diabetes and a control group of 30 non-diabetic people (15 female, 15 male). They were matched for age, gender and BMI. Blood sampling was taken from each participant to measure the blood levels of MDA and chromium and the relation between them was assessed by the Pearson correlation test. Received: 15/June/2009 1 Corresponding author: Nutrition and Biochemistry Dept., Faculty of Health, Tehran Univ. of Med. Sci. Tehran, Iran. Tel: 021-88954924 E-mail: esyussefirad2@yahoo.com Results: Mean serum chromium in diabetic group was found 0.80±0.28^gr/dl, but it was 1.19±0.33^gr/dl in control group (P<0.001). Moreover, serum level of MDA was significantly higher in diabetic group compared to the control group (2.02±0.88^mol/lit versus 1.13±0.64^mol/lit, P<0.001). The correlation test indicated that there was no significant association between serum levels of chromium with the serum level of MDA in these patients (P>0.05). Conclusion: Findings of this study do not show any relation between the serum levels of chromium and malondialdehyde, in spite of a decreased serum concentration of chromium and an increased level in serum MDA in diabetic patients.