اثر توكليجه بر علايم خستگي ، تهوع و استفراغ ناشي از ديسمنوره اوليه

Effect of Stachys lavandulifolia on fatigue, nausea and vomiting associated with primary dysmenorrheal

زمينه: با توجه به اهميت و شيوع ديسمنوره و اثرات آن بر زندگي نيمي از جمعيت جهان؛ يعني زنان، مطالعه در مورد درمان آن ضروري به نظر مي رسد. هدف: مطالعه به منظور تعيين اثر توكليجه برعلايم خستگي، تهوع و استفراغ ناشي از ديسمنوره اوليه انجام شد. مواد و روش ها: در اين كارآزمايي باليني، 50 دختر 18 تا 25 ساله با وزن 50 تا 60 كيلوگرم مبتلا به ديسمنوره اوليه انتخاب شدند. شدت خستگي، تهوع و استفراغ با خط كش عيني درد، اندازه گيري شد. اين افراد به مدت سه دوره متوالي، 2 روز قبل تا 3 روز بعد از شروع قاعدگي 10 گرم پودر گل گياه توكليجه را به روش دم كرده روزي 3 بار مصرف كردند. قبل و بعد از مصرف دارو شدت تهوع، استفراغ و خستگي ثبت شد. عوارض جانبي تجويز دارو نيز پس از درمان بررسي شدند. در نهايت داده ها با استفاده از آزمون آماري تي و مجذور كاي تحليل شدند. يافته ها: بعد از مصرف توكليجه خستگي و تهوع ناشي از به طور معني داري كاهش يافت (001/0P < )؛ ولي شدت استفراغ بعد از مصرف توكليجه در مقايسه با قبل از مصرف دارو اختلاف آماري معني داري نداشت. نتيجه گيري: استفاده از توكليجه به شيوه سنتي آن مي تواند باعث كاهش علايم خستگي و تهوع ناشي از ديسمنوره اوليه شود؛ اما بر استفراغ ناشي از آن موثر نيست.

Background: Because of importance and outbreak of dysmenorrhea and Itʹs effect on life of 50% of population in the world(women), this study was done. Objective: To evaluate the therapeutic effects of Stachys Ivandulifolia on fatigue, nausea, and vomiting associated with primary dysmenorrhea. Methods: This was a randomized clinical trial performed on 50 women aged 18-25 years and 50-60 kg whight suffering from primary dysmenorrhea. Fatigue, nausea, and vomiting were evaluated by visual analogue scale (VAS). Initially, the study population was requested to consume the Stachys Ivandulifolia flowers at a dose of 10 gr of brewed powder three time a day and for a total of 5 days (2 days before pain to 3 days after pain), based on a common traditional administration. Later, the members of both groups were followed up for three cycles. Fatigue, nausea, and vomiting as well as the side-effects were evaluated following consumption of brewed powder of Stachys Ivandulifolia flowers. Statistical analysis was performed using t-test and chi-square test. Findings: Following consumption of Stachys Ivandulifolia the level of fatigue considerably reduced among test group and the difference was significant (p=0/000), statistically. Likewise, a significant difference in severity of nausea between the test and control groups was shown (p=0/006). No statistically significant difference regarding the severity of vomiting was established between two groups. Conclusion: According to our data, it could be concluded that the use of Stachys Ivandulifolia, based on a traditional administration, causes favorable therapeutic effects by reducing the degree of fatigue and nausea in primary dysmenorrhea with no obvious side-effect yet with no effect on vomiting.