ارزيابي مصرف منطقي سفترياكسون در بخش هاي داخلي و جراحي

Assessment of reasonable use of Ceftriaxone in internal and surgical wards

Abstract Aims: Inappropriate use of antibiotics causes serious problems such as microorganism resistance and may lead to several side effects and even death. Drug Utilization Review studies are suitable means of drug use evaluation and revealing immethodical drug utilization trends and proposing proper solutions. This study was designed to evaluate the utilization trend of Ceftriaxone in Iran. Materials & Methods: This descriptive cross-sectional study was performed on 300 inpatients of internal and surgical wards in an educational hospital in Tehran for two six month periods in years 2008 and 2009. A protocol containing prescribing and consumption rules for ceftriaxone was prepared based on ministry of health protocol and reference books. Essential data were collected through a questionnaire designed by authors. Data was analyzed by SPSS 16. Results: Of 300 patients who entered the study, 266 cases had received the drug as surgical antibiotic prophylaxis that 32% were according to protocol and 68% were not completely according to the protocol. In 34% cases who received ceftriaxone for infection treatment, 17.4% were according to the protocol and 85.3% were not. Conclusion: There is a remarkable incoherence between current ceftriaxone use trend and the designed protocol in this study; therefore more attention should be paid to available guidelines. Establishing better surveillance methods and medical staff training programs is suggested. Keywords: Ceftriaxone, Antibiotic, Prophylaxis, Drug Utilization Review