بررسي توكسيكو پاتولوژي نانو داروي توليد شده بر پايه نانوليپوزوم بر روي موش

Toxicopathologic study of nanodrug produced based on nanoliposomes on mouse.

Nanoscience growth in the past few years, attention has attracted many people. However, no ill side effects, it was seen. In this study, nanoliposomes as carriers of morphine used. After implementation of the synthesis process of nano Liposome morphine on mice with race balb /c tested. Thus, mice with a weight of 27 ± 2 gr were used. In mice with controlled temperature and humidity were kept in darkness for 12 hours and to allow them free access to food and water were given. 10 micro liters of test solution was injected into the spinal column. 30 minutes later determine TFL, 8 mice from each group received injections into the spinal fluid. Regression analysis of dose response curves for morphine and normal Liposome important interaction between dose and curves to bring proof of (P <0/ 004). Duration of anesthesia, increasing the dose of morphine Liposome compared with conventional morphine increased. The three groups of eight mice with the number of carbon dioxide inhalation Coward (C02), for 1 minute 8 hours after injection were sacrificed and organs, including the desired brain, spinal cord, spleen, liver and kidney removed and underwent pathologic review. Comparison of histopathologic tissue in the brain, spinal cord, liver, spleen and kidneys at any pathology including extensive hematoma, inflammation, degeneration, necrosis and other changes were observed.