اثر 8 هفته تمرين مقاومتي دايره اي با شدت بالا بر سطوح پلاسمايي چمرين و كنترل گلايسميك در بيماران مرد مبتلا به ديابت نوع 2

Abstract Very little data exist on the effects of resistance training in diabetics. It has been shown that intensity of resistance exercise, the more important variable than exercise volume in patients with type 2 diabetes. Chemerin is a newly discovered adipokine that has been shown to induce insulin resistance in skeletal muscles. Thus, recent study investigate the role of 8 weeks of high intensity circuit resistance training on plasma chemerin levels in diabetic men. A total of 18 sedentary, overweight men with type 2 diabetes (age: 48.5±7.73 yr, weight: 79.41±12.6 kg and BMI: 27.29±4.38 kg/m2), were randomized to experimental (n=10) and control (n=8) groups. Chemerin, insulin, fasting blood glucose (FBG), glycosylated hemoglobin (HbA1C) levels and insulin resistance index (HOMA-IR) were measured before and 60h after the training period. Plasma chemerin levels decreased significantly (p=0.01) in resistance training group, and exhibited significant reductions in plasma insulin (p=0.01) and glucose (p=0.04). Resistance training reduced HOMA-IR (p=0.01), but HbA1C remained unchanged (p > 0.05). Reduced plasma chemerin concentration may contribute to improved insulin sensitivity. It seems that circuit resistance training with high-intensity can be focused as a prevention approach in type 2 diabetes, but may not be appropriate for some individuals. Key words: Type 2 diabetes, High intensity circuit resistance training, Chemerin, Insulin resistance