خوراكي بر كاهش عوارض حاد پوستي مخاطي و سيستميك آسيترتين در پسوريازپس E بررسي اثر تجويز ويتامين

Concomitant Use of Vitamin E and Acitretin for Decreasing Acute Systemic and Mucocutaneous Side-Effects of Acitretin in Psoriatic Patients

Acitretin treatment is frequently associated with acute, dose-dependent cutaneous and systemic side effects. Recent studies have shown that concomitant administration of vitamin E could ameliorate the side effects of high-dose retinoid therapy in oncology. The purpose of the present study was to determine the effects of vitamin E on the side-effects of acitretin for treatment of psoriasis. Thirty patients were randomly allocated to one of two therapeutic regimens (acitretin alone, and acitretin 0.7 mg/kg together with vitamin E, 800 IU/day) for 8 weeks. The incidence and severity of 16 adverse effects, (cheilitis, pruritus, xerosis,...) were assessed in 3 follow up visits at the end of the 2nd, 4th and 8th weeks. Vitamin E did not decrease the incidence and severity of side effects associated with acitretin therapy in psoriasis except for some degree of improvement in palmoplantar peeling only in the first follow-up visit. In this study, vitamin E did not significantly ameliorate the acitretin adverse effects in the treatment of psoriasis.