مقايسه اثرات آرام بخش تجويز ميدازولام داخل بيني و كتامين خوراكي قبل از انجام اعمال جراحي در كودكان

Comparison of the Effect of Intranasal Midazolam and Oral Ketamine in Pediatrics Premedication

The efficacy and side effects of intranasal midazolam and oral ketamine for pediatric premedication was studied. In this double blind trial 102 children who scheduled for elective surgery were randomly assigned to three different groups in order to receive intranasal midazolam (0.3mg/kg), oral ketamine (0.2mg/kg) or intranasal placebo (0.06m1/kg of normal saline). We measured levels of acceptance of medication, sedation, hemodynamic variables, fear, cooperation, and reaction to separation from parents. The three groups were homogeneous. Total questionnaire scores and its subscales (sedation, reaction to separation from parents, fear and cooperation) were significantly higher in midazolam group and lower in placebo one. Considering the results of this study it seems that both midazolam and ketamine are useful and that midazolam is effective. It is also recommended that the efficacy of intranasal midazolam and ketamine to be compared as well.