Title List مقالات لاتين Discovery and in vitro/in vivo studies of tetrazole derivatives as Kv1.5 blockers Discrete dislocation plasticity analysis of the grain size dependence of the flow strength of polycrystals

بر اساس عنوان

1

Discovery and in vitro/in vivo studies of tetrazole derivatives as Kv1.5 blockers

2

Discovery and initial development of a novel class of antibacterials: Inhibitors of Staphylococcus aureus transcription/translation

3

Discovery and initial SAR of 2-amino-5-carboxamidothiazoles as inhibitors of the Src-family kinase p56Lck

4

Discovery and initial SAR of 3-(1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-ones as inhibitors of insulin-like growth factor 1-receptor (IGF-1R)

5

Discovery and Initial SAR of Arylsulfonylpiperazine Inhibitors of 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1)

6

Discovery and initial SAR of imidazoquinoxalines as inhibitors of the Src-family kinase p56Lck

7

Discovery and initial SAR of inhibitors of interleukin-1 receptor-associated kinase-4

8

Discovery and initial structure–Activity relationships of trisubstituted ureas as thrombin receptor (PAR-1) antagonists

9

Discovery and integration of univariate patterns from daily individual organ-failure scores for intensive care mortality prediction

10

Discovery and investigation of a novel class of thiophene-derived antagonists of the human glucagon receptor

11

Discovery and molecular cloning of piscidin-5-like gene from the large yellow croaker (Larimichthys crocea)

12

Discovery and optimisation of potent, selective, ethanolamine inhibitors of bacterial phenylalanyl tRNA synthetase

13

Discovery and optimization of (R)-prolinol-derived agonists of the Growth Hormone Secretagogue receptor (GHSR)

14

Discovery and optimization of 2-aryl oxazolo-pyrimidines as adenosine kinase inhibitors using liquid phase parallel synthesis

15

Discovery and Optimization of a Natural HIV-1 Entry Inhibitor Targeting the gp41 Fusion Peptide

16

Discovery and optimization of a novel series of liver X receptor-α agonists

17

Discovery and optimization of a series of quinazolinone-derived antagonists of CXCR3

18

Discovery and optimization of indole pyrrolothiazole paf antagonists

19

Discovery and optimization of nonpeptide HIV-1 protease inhibitors Original Research Article

20

Discovery and optimization of novel, non-steroidal glucocorticoid receptor modulators

21

Discovery and optimization of pyridazinone non-nucleoside inhibitors of HIV-1 reverse transcriptase

22

Discovery and optimization of substituted piperidines as potent, selective, CNS-penetrant α4β2 nicotinic acetylcholine receptor potentiators

23

Discovery and parallel synthesis of a new class of cathepsin k inhibitors

24

Discovery and preclinical studies of 5-isopropyl-6-(5-methyl-1,3,4-oxadiazol-2-yl)-N-(2-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine (BMS-645737), an in vivo active potent VEGFR-2 inhibitor

25

Discovery and preliminary evaluation of 5-(4-phenylbenzyl)oxazole-4-carboxamides as prostacyclin receptor antagonists

26

Discovery and preliminary structure–activity relationship studies of novel benzotriazine based compounds as Src inhibitors

27

Discovery and SAR development of 2-(phenylamino) imidazolines as postacyclin receptor antagonists

28

Discovery and SAR development of thienopyridones: A class of small molecule AMPK activators

29

Discovery and SAR of 1,3,4-thiadiazole derivatives as potent Abl tyrosine kinase inhibitors and cytodifferentiating agents

30

Discovery and SAR of 2-(1-propylpiperidin-4-yl)-1H-benzimidazole-4-carboxamide: A potent inhibitor of poly(ADP-ribose) polymerase (PARP) for the treatment of cancer Original Research Article

31

Discovery and SAR of 2-amino-5-(thioaryl)thiazoles as potent and selective Itk inhibitors

32

Discovery and SAR of 2-amino-5-[(thiomethyl)aryl]thiazoles as potent and selective Itk inhibitors

33

Discovery and SAR of 2-aminothiazole inhibitors of cyclin-dependent kinase 5/p25 as a potential treatment for Alzheimer’s disease

34

Discovery and SAR of 4-amino-2-biarylbutylurea MCH 1 receptor antagonists through solid-phase parallel synthesis

35

Discovery and SAR of biaryl piperidine MCH1 receptor antagonists through solid-phase encoded combinatorial synthesis

36

Discovery and SAR of diarylsulfide cyclopropylamide LFA-1/ICAM-1 interaction antagonists

37

Discovery and SAR of hydrazide antagonists of the pituitary adenylate cyclase-activating polypeptide (PACAP) receptor type 1 (PAC1-R)

38

Discovery and SAR of isonicotinamide BACE-1 inhibitors that bind β-secretase in a N-terminal 10s-loop down conformation

39

Discovery and SAR of new benzazepines as potent and selective 5-HT2C receptor agonists for the treatment of obesity

40

Discovery and SAR of novel [ and ]Naphthyridines as potent inhibitors of spleen tyrosine kinase (SYK)

41

Discovery and SAR of novel 4-thiazolyl-2-phenylaminopyrimidines as potent inhibitors of spleen tyrosine kinase (SYK)

42

Discovery and SAR of novel, potent and selective protein tyrosine phosphatase 1B inhibitors

43

Discovery and SAR of Org 24598—A Selective Glycine Uptake Inhibitor

44

Discovery and SAR of oxindole–pyridine-based protein kinase B/Akt inhibitors for treating cancers

45

Discovery and SAR of potent, orally available and brain-penetrable 5,6-dihydro-4H-3-thia-1-aza-benzo[e]azulen- and 4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulen derivatives as neuropeptide Y Y5 receptor antagonists

46

Discovery and SAR of trisubstituted thiazolidinones as CCR4 antagonists

47

Discovery and SAR studies of a novel series of noncovalent cathepsin S inhibitors

48

Discovery and SAR studies of novel GlyT1 inhibitors

49

Discovery and SAR study of novel dihydroquinoline containing glucocorticoid receptor ligands

50

Discovery and SAR study of novel dihydroquinoline-containing glucocorticoid receptor agonists

51

Discovery and Significance of Eclogite-Granitoid Belts in Northwest China

52

Discovery and stereoselective synthesis of the novel isochroman neurokinin-1 receptor antagonist ‘CJ-17,493’ Original Research Article

53

Discovery and Structural Characterization of a New Inhibitor Series of HIV-1 Nucleocapsid Function: NMR Solution Structure Determination of a Ternary Complex Involving a 2:1 Inhibitor/NC Stoichiometry

54

Discovery and structure–activity relationship analysis of Staphylococcus aureus sortase A inhibitors Original Research Article

55

Discovery and structure–activity relationship of 2-phenyl-oxazole-4-carboxamide derivatives as potent apoptosis inducers

56

Discovery and structure–activity relationship of coumarin derivatives as TNF-α inhibitors

57

Discovery and structure–activity relationship of N-phenyl-1H-pyrazolo[3,4-b]quinolin-4-amines as a new series of potent apoptosis inducers Original Research Article

58

Discovery and structure–activity relationship studies of a novel and specific peptide motif, pro-X-X-X-asp-X, as a platelet fibrinogen receptor antagonist Original Research Article

59

Discovery and structure–activity relationship studies of indole derivatives as liver X receptor (LXR) agonists

60

Discovery and structure–activity relationships of 2-benzylpyrrolidine-substituted aryloxypropanols as calcium-sensing receptor antagonists

61

Discovery and structure–activity relationships of new steroidal compounds bearing a carboxy-terminal side chain as androgen receptor pure antagonists

62

Discovery and structure–activity relationships of novel selective norepinephrine and dual serotonin/norepinephrine reuptake inhibitors

63

Discovery and structure–activity relationships of novel sulfonamides as potent PTP1B inhibitors

64

Discovery and structure-activity studies of a novel series of pyrido[2,3-d]pyrimidine tyrosine kinase inhibitors

65

Discovery and study of dinosaurs from Spain: The contribution of Albert F. de Lapparent

66

Discovery and synthesis of a novel and selective drug-like P2X1 antagonist

67

Discovery and synthesis of a novel series of quinoline-based thrombin receptor (PAR-1) antagonists

68

Discovery and synthesis of a potent sulfonamide ETB selective antagonist

69

Discovery and synthesis of novel phosphine-based ligands for aryl aminations

70

Discovery and synthesis of tetrahydroindolone derived semicarbazones as selective Kv1.5 blockers

71

Discovery and synthesis of tetrahydroindolone-derived carbamates as Kv1.5 blockers

72

Discovery and the structural basis of a novel p21-activated kinase 4 inhibitor

73

Discovery and Understanding of Transition-Metal-Catalyzed Aromatic Substitution Reactions

74

Discovery and validation of new protein biomarkers for urothelial cancer: A prospective analysis: Theodorescu D, Wittke S, Ross MM, Walden M, Conaway M, Just I, Mischak H, Frierson HF, Department of Molecular Physiology, Mellon Prostate Cancer Institute,

75

Discovery from combinatorial heterogeneous catalysis: A new class of catalyst for ethane oxidative dehydrogenation at low temperatures Original Research Article

76

Discovery Learning Strategy in Geographical Education: A Sample of Lesson Design

77

Discovery learning, representation, and explanation within a computer-based simulation: finding the right mix

78

Discovery limits in prospective studies

79

Discovery limits in prospective studies

80

Discovery of (−)-6-[2-[4-(3-fluorophenyl)-4-hydroxy-1-piperidinyl]-1-hydroxyethyl]-3,4-dihydro-2(1H)-quinolinone—A potent NR2B-selective N-methyl d-aspartate (NMDA) antagonist for the treatment of pain

81

Discovery of (2S)-N-[(1R)-2-[4-cyclohexyl-4-[[(1,1-dimethylethyl)amino]carbonyl]-1-piperidinyl]-1-[(4-fluorophenyl)methyl]-2-oxoethyl]-4-methyl-2-piperazinecarboxamide (MB243), a potent and selective melanocortin subtype-4 receptor agonist

82

Discovery of (naphthalen-4-yl)(phenyl)methanones and N-methyl-N-phenylnaphthalen-1-amines as new apoptosis inducers using a cell- and caspase-based HTS assay

83

Discovery of (R)-1-[2-Hydroxy-3-(4-hydroxy-phenyl)-propyl]-4-(4-methyl-benzyl)-piperidin-4-ol: A Novel NR1/2B Subtype Selective NMDA Receptor Antagonist

84

Discovery of (S)-2-((S)-2-(3,5-difluorophenyl)-2-hydroxyacetamido)-N-((S,Z)-3-methyl-4-oxo-4,5-dihydro-3H-benzo[d][1,2]diazepin-5-yl)propanamide (BMS-433796): A γ-secretase inhibitor with Aβ lowering activity in a transgenic mouse model of Alzheimer’s dis

85

Discovery of (Z)-2-phenyl-3-(1H-pyrrol-2-yl)acrylonitrile derivatives active against Haemonchus contortus and Ctenocephalides felis (cat flea)

86

Discovery of [(3-bromo-7-cyano-2-naphthyl)(difluoro)methyl]phosphonic acid, a potent and orally active small molecule PTP1B inhibitor

87

Discovery of [7-(2,6-dichlorophenyl)-5-methylbenzo [1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-ylethoxy)phenyl]amine—a potent, orally active Src kinase inhibitor with anti-tumor activity in preclinical assays

88

Discovery of +(2-{4-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethoxy]phenyl}-cyclopropyl)acetic acid as potent and selective αvβ3 inhibitor: Design, synthesis, and optimization Original Research Article

89

Discovery of 1-(4-phenoxypiperidin-1-yl)-2-arylaminoethanone stearoyl-CoA desaturase 1 inhibitors

90

Discovery of 1,1-dioxo-1,2,6-thiadiazine-5-carboxamide derivatives as cannabinoid-like molecules with agonist and antagonist activity Original Research Article

91

Discovery of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid diamides that increase CFTR mediated chloride transport

92

Discovery of 1,3-disubstituted-1H-pyrrole derivatives as potent Melanin-Concentrating Hormone Receptor 1 (MCH-R1) antagonists

93

Discovery of 1,4-dihydroindeno[1,2-c]pyrazoles as a novel class of potent and selective checkpoint kinase 1 inhibitors Original Research Article

94

Discovery of 1,7-cyclized indoles as a new class of potent and highly selective human β3-adrenergic receptor agonists with high cell permeability Original Research Article

95

Discovery of 17,18O-rich material from meteorite by direct-imaging method using stigmatic-SIMS and 2D ion detector

96

Discovery of 1-amino-4-phenylcyclohexane-1-carboxylic acid and its influence on agonist selectivity between human melanocortin-4 and -1 receptors in linear pentapeptides

97

Discovery of 1-benzoyl-3-cyanopyrrolo[1,2-a]quinolines as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay. Part 1: Structure–activity relationships of the 1- and 3-positions

98

Discovery of 2,3,5-trisubstituted pyridine derivatives as potent Akt1 and Akt2 dual inhibitors

99

Discovery of 2,3-diaryl-1,3-thiazolidin-4-ones as potent anti-HIV-1 agents

100

Discovery of 2,4,6-trisubstituted N-arylsulfonyl piperidines as γ-secretase inhibitors

101

Discovery of 23 Natural Tubulysins from Angiococcus disciformis An d48 and Cystobacter SBCb004 Original Research Article

102

Discovery of 2-amino-6-carboxamidobenzothiazoles as potent Lck inhibitors

103

Discovery of 2-amino-heteroaryl-benzothiazole-6-anilides as potent p56lck inhibitors

104

Discovery of 2-iminobenzimidazoles as a new class of trypanothione reductase inhibitor by high-throughput screening

105

Discovery of 2-Phenyl-3-sulfonylphenyl-indole derivatives as a new class of selective COX-2 inhibitors Original Research Article

106

Discovery of 2-pyrimidyl-5-amidothiophenes as potent inhibitors for AKT: Synthesis and SAR studies

107

Discovery of 3-(4-bromophenyl)-6-nitrobenzo[1.3.2]dithiazolium ylide 1,1-dioxide as a novel dual cyclooxygenase/5-lipoxygenase inhibitor that also inhibits tumor necrosis factor-α production Original Research Article

108

Discovery of 3,3-dimethyl-5-hydroxypipecolic hydroxamate-based inhibitors of aggrecanase and MMP-13

109

Discovery of 3,5-bis(trifluoromethyl)benzyl l-arylglycinamide based potent CCR2 antagonists

110

Discovery of 3-acetyl-4-hydroxy-2-pyranone derivatives and their difluoridoborate complexes as a novel class of HIV-1 integrase Inhibitors Original Research Article

111

Discovery of 3-Amino-4-Chlorophenyl P1 as a novel and potent benzamidine mimic via solid-phase synthesis of an isoxazoline library

112

Discovery of 3-aminopiperidines as potent, selective, and orally bioavailable dipeptidyl peptidase IV inhibitors

113

Discovery of 3-aryl-3-methyl-1H-quinoline-2,4-diones as a new class of selective 5-HT6 receptor antagonists

114

Discovery of 3-arylpropionic acids as potent agonists of sphingosine-1-phosphate receptor-1 (S1P1) with high selectivity against all other known S1P receptor subtypes

115

Discovery of 3-hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles as potent MEK1 inhibitors

116

Discovery of 3-OH-3-methylpipecolic hydroxamates: Potent orally active inhibitors of aggrecanase and MMP-13

117

Discovery of 4-(dimethylamino)quinazolines as potent and selective antagonists for the melanin-concentrating hormone receptor 1

118

Discovery of 4,5-Diphenyl-1,2,4-triazole Derivatives as a Novel Class of Selective Antagonists for the Human V1A Receptor Original Research Article

119

Discovery of 4′-(1,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-benzonitriles and 4′-(1,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-pyridine-2′-carbonitriles as potent checkpoint kinase 1 (Chk1) inhibitors

120

Discovery of 4′-[(Imidazol-1-yl)methyl]biphenyl-2-sulfonamides as dual endothelin/Angiotensin II receptor antagonists

121

Discovery of 4-amino-5,6-biaryl-furo[2,3-d]pyrimidines as inhibitors of Lck: Development of an expedient and divergent synthetic route and preliminary SAR

122

Discovery of 4-aryl-2-oxo-2H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay

123

Discovery of 4-aryl-4H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay. 2. Structure–activity relationships of the 7- and 5-, 6-, 8-positions

124

Discovery of 4-aryl-4H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based HTS assay. Part 5: Modifications of the 2- and 3-positions

125

Discovery of 4-heteroarylbicyclo[2.2.2]octyltriazoles as potent and selective inhibitors of 11β-HSD1: Novel therapeutic agents for the treatment of metabolic syndrome

126

Discovery of 4-substituted-8-(2-hydroxy-2-phenyl-cyclohexyl)-2,8-diaza-spiro[4.5]decan-1-one as a novel class of highly selective GlyT1 inhibitors with improved metabolic stability

127

Discovery of 5-(4-hydroxy-6-methyl-2-oxo-2H-pyran-3-yl)-7-phenyl-(E)-2,3,6,7-tetrahydro-1,4-thiazepines as a new series of apoptosis inducers using a cell- and caspase-based HTS assay

128

Discovery of 5-HT6 receptor ligands based on virtual HTS

129

Discovery of 5-Hydroxyalkyl-4-phenylpyridines as a New Class of Glucagon Receptor Antagonists

130

Discovery of 60Ge and 64Se

131

Discovery of 6-ethyl-2,4-diaminopyrimidine-based small molecule renin inhibitors

132

Discovery of 7α-substituted dihydrotestosterones as androgen receptor pure antagonists and their structure–activity relationships Original Research Article

133

Discovery of a 7 second anomalous X-ray pulsar in the distant Milky Way

134

Discovery of a Binary Active Galactic Nucleus in the Ultraluminous Infrared Galaxy NGC 6240 Using Chandra

135

Discovery of a binary Centaur

136

Discovery of a c.370 Ma granitic gneiss clast from the Hwanggangri pebble-bearing phyllite in the Okcheon metamorphic belt, Korea

137

Discovery of a coherent 87.65-minute oscillation of the suspected cataclysmic variable NSV 2872 (Aur 2)

138

Discovery of a dihydropyrimidine series of molecules that selectively mimic the biological actions of calcitonin

139

Discovery of a dismembered metamorphic sole in the Saga ophiolitic mélange, South Tibet: Assessing an Early Cretaceous disruption of the Neo-Tethyan supra-subduction zone and consequences on basin closing

140

Discovery of a dopamine D4 selective PET ligand candidate taking advantage of a click chemistry based REM linker

141

Discovery of a double impact crater in Libya: the astrobleme of Arkenu

142

Discovery of a dust cloud next to (sigma)Orionis

143

Discovery of a faint R-band drop-out: A strongly reddened lensed star forming galaxy at z = 1.68

144

Discovery of a giant deep-sea valley in the Indian Ocean, off eastern Africa: The Tanzania channel

145

Discovery of a helium-core white dwarf progenitor

146

Discovery of a hidden BIF deposit in Anhui province, China by integrated geological and geophysical investigations

147

Discovery of a highly orally bioavailable c-5-[6-(4-Methanesulfonyloxyphenyl)hexyl]-2-methyl-1,3-dioxane-r-2-carboxylic acid as a potent hypoglycemic and hypolipidemic agent

148

Discovery of a highly potent series of oxazole-based phosphodiesterase 4 inhibitors

149

Discovery of a highly potent, functionally-selective muscarinic M1 agonist,WAY-132983 using rational drug design and receptor modelling

150

Discovery of a huge sector collapse at the Nisyros volcano, Greece, by on-land and offshore geological-structural data

151

Discovery of a Late Ordovician Foliomena fauna in the Tarim desert, Northwest China

152

Discovery of a Low-Mass Bipolar Molecular Outflow from L1014-IRS with the Submillimeter Array

153

Discovery of a luminous water megamaser in the FR II radiogalaxy 3C 403

154

Discovery of a magnetic field in the Slowly Pulsating B star Cassiopeiae

155

Discovery of a Magnetic Ionic Liquid [bmim]FeCl4

156

Discovery of a mass grave of Napoleonic period in Lithuania (1812, Vilnius)

157

Discovery of a Mesolithic burial near the painted rock-shelter of Ban Tha Si (Lampang province, Northern Thailand): Implications for regional mortuary practices

158

Discovery of a missing disease spreader

159

Discovery of a muscarinic M3 receptor antagonist with high selectivity for M3 over M2 receptors among 2-[(1S,3S)-3-sulfonylaminocyclopentyl]phenylacetamide derivatives Original Research Article

160

Discovery of a N′-hydroxyphenylformamidine derivative HET0016 as a potent and selective 20-HETE synthase inhibitor

161

Discovery of a Nearby Halo White Dwarf with Proper Motion (mu) = 2n55 yr^-1

162

Discovery of a Neoproterozoic basin in the Prydz belt in East Antarctica and its implications for Gondwana assembly and ultrahigh temperature metamorphism

163

Discovery of a new 2.3 s isomer in neutron-rich 174Tm

164

Discovery of a new catalytically active and selective zeolite (ITQ-30) by high-throughput synthesis techniques

165

Discovery of a new chemical lead for a matrix metalloproteinase inhibitor Original Research Article

166

Discovery of a new class of 4-anilinopyrimidines as potent c-Jun N-terminal kinase inhibitors: Synthesis and SAR studies

167

Discovery of a new class of p38 kinase inhibitors

168

Discovery of a new class of potent, selective, and orally active prostaglandin D2 receptor antagonists Original Research Article

169

Discovery of A New Class of Pulsating Stars: Gravity-Mode Pulsators among Subdwarf B Stars

170

Discovery of a new cyclooxygenase-2 lead compound through 3-D database searching and combinatorial chemistry

171

Discovery of a new element ‘nipponium’: re-evaluation of pioneering works of Masataka Ogawa and his son Eijiro Ogawa

172

Discovery of a new Fe-type nitrile hydratase efficiently hydrating aliphatic and aromatic nitriles by genome mining

173

Discovery of a new hydrothermal vent based on an underwater, high-resolution geophysical survey

174

Discovery of a new insecticide lead by optimizing a target-diverse scaffold: Tetrazolinone derivatives Original Research Article

175

Discovery of a New Role of Human Resistin in Hepatocyte Low-Density Lipoprotein Receptor Suppression Mediated in Part by Proprotein Convertase Subtilisin/Kexin Type 9

176

Discovery of a new species of Lonchodryinus from Madagascar (Hymenoptera, Dryinidae)

177

Discovery of a nonpeptidic small molecule antagonist of the human platelet thrombin receptor (PAR-1)

178

Discovery of a novel abl tyrosine kinase inhibitor that selectively induces apoptosis of bcr-abl-positive leukemic cells

179

Discovery of a novel and potent series of dianilinopyrimidineurea and urea isostere inhibitors of VEGFR2 tyrosine kinase

180

Discovery of a novel and potent series of thieno[3,2-b]pyridine-based inhibitors of c-Met and VEGFR2 tyrosine kinases

181

Discovery of a novel antimicrobial peptide using membrane binding-based approach

182

Discovery of a novel benzyloxyisoquinoline derivative with potent anti-Helicobacter pylori activity

183

Discovery of a novel bicycloproline P2 bearing peptidyl α-ketoamide LY514962 as HCV protease inhibitor

184

Discovery of a novel CCR3 selective antagonist

185

Discovery of a novel class of 1,3-dioxane-2-carboxylic acid derivatives as subtype-selective peroxisome proliferator-activated receptor α (PPARα) agonists

186

Discovery of a novel class of 2-ureido thiophene carboxamide checkpoint kinase inhibitors

187

Discovery of a novel class of benzazepinone Nav1.7 blockers: Potential treatments for neuropathic pain

188

DISCOVERY OF A NOVEL CLASS OF BK CHANNEL OPENERS: ENANTIOSPECIFIC SYNTHESIS AND BK CHANNEL OPENING ACTIVITY OF 3-(5-CHLORO-2-HYDROXYPHENYL)-1,3-DIHYDRO-3-HYDROXY-6-(TRIFLUOROMETHYL)-2H-INDOL-2-ONE

189

Discovery of a novel class of PPARδ partial agonists

190

Discovery of a novel class of selective human CB1 inverse agonists

191

Discovery of a Novel Family of CDK Inhibitors with the Program LIDAEUS: Structural Basis for Ligand-Induced Disordering of the

192

Discovery of a novel indole series of EP1 receptor antagonists by scaffold hopping

193

Discovery of a novel lead structure for anti-malarials Original Research Article

194

Discovery of a novel one-step RuO4-catalysed tandem oxidative polycyclization/double spiroketalization process. Access to a new type of polyether bis-spiroketal compound displaying antitumour activity

195

Discovery of a novel potent Na+/Ca2+ exchanger inhibitor: design, synthesis and structure–activity relationships of 3,4-dihydro-2(1H)-quinazolinone derivatives

196

Discovery of a novel series of 6-azauracil-based thyroid hormone receptor ligands: potent, TRβ subtype-selective thyromimetics

197

Discovery of a novel series of DHODH inhibitors by a docking procedure and QSAR refinement

198

Discovery of a novel series of inhibitors of human cytomegalovirus primase

199

Discovery of a novel series of nonsteroidal androgen receptor modulators: 5- or 6-oxachrysen-2-ones

200

Discovery of a novel series of Notch-sparing γ-secretase inhibitors

201

Discovery of a novel series of selective MMP inhibitors: Identification of the γ-sulfone-thiols

202

Discovery of a novel small molecule binding site of human survivin

203

Discovery of a novel small molecule, 1-ethoxy-3-(3,4-methylenedioxyphenyl)-2-propanol, that induces apoptosis in A549 human lung cancer cells Original Research Article

204

Discovery of a novel submicromolar inhibitor of the lymphoid specific tyrosine phosphatase

205

Discovery of a novel tetrahydroacridine acetylcholinesterase inhibitor through an indexed combinatorial library Original Research Article

206

Discovery of a novel, potent and orally active series of γ-lactams as selective NK1 antagonists

207

Discovery of a novel, potent and selective human β3-adrenergic receptor agonist

208

Discovery of a nuclease-resistant, non-natural dinucleotide that inhibits HIV-1 integrase

209

Discovery of a potent and selective 5-ht5A receptor antagonist by high-throughput chemistry

210

Discovery of a potent and selective agonist of the prostaglandin EP4 receptor

211

Discovery of a potent and selective Aurora kinase inhibitor

212

Discovery of a potent and selective c-Kit inhibitor for the treatment of inflammatory diseases

213

Discovery of a potent and selective COX-2 inhibitor in the alkoxy lactone series with optimized metabolic profile

214

Discovery of a potent and selective series of pyrazole bacterial methionyl-tRNA synthetase inhibitors

215

Discovery of a potent and selective αvβ3 integrin antagonist with strong inhibitory activity against neointima formation in rat balloon injury model

216

Discovery of a potent CDK2 inhibitor with a novel binding mode, using virtual screening and initial, structure-guided lead scoping

217

Discovery of a potent phenolic N1-benzylidene–pyridinecarboxamidrazone selective against Gram-positive bacteria

218

Discovery of a potent, non-triketone type inhibitor of 4-hydroxyphenylpyruvate dioxygenase

219

Discovery of a potent, selective and orally active canine COX-2 inhibitor, 2-(3-difluoromethyl-5-phenyl-pyrazol-1-yl)-5-methanesulfonyl-pyridine

220

Discovery of a potent, selective, and less flexible selective norepinephrine reuptake inhibitor (sNRI)

221

Discovery of a prehistoric site at Sao Din (Nanoi, Nan province, Northern Thailand): Stone tools and new geological insights

222

Discovery of a Proneurogenic, Neuroprotective Chemical

223

Discovery of a recent, natural whale fall on the continental slope off Anvers Island, western Antarctic Peninsula

224

Discovery of a recurrent lava lake on Saunders Island (South Sandwich Islands) using AVHRR imagery

225

Discovery of a reductase-producing strain recombinant E. coli CCZU-A13 using colorimetric screening and its whole cell-catalyzed biosynthesis of ethyl (R)-4-chloro-3-hydroxybutanoate

226

Discovery of a Secreted Tumor Suppressor Provides a Promising Therapeutic Strategy for Follicular Lymphoma

227

Discovery of a series of (4,5-Dihydroimidazol-2-yl)-biphenylamine 5-HT7 agonists

228

Discovery of a series of acrylic acids and their derivatives as chemical leads for selective EP3 receptor antagonists Original Research Article

229

Discovery of a series of aminopiperidines as novel iNOS inhibitors

230

Discovery of a series of pyrrolidine-based endothelin receptor antagonists with enhanced ETA receptor selectivity Original Research Article

231

Discovery of a Small Molecule that Inhibits the Interaction of Anthrax Edema Factor with Its Cellular Activator, Calmodulin Original Research Article

232

Discovery of a strong magnetic field in the rapidly rotating B2Vn star HR7355

233

Discovery of a substituted 8-arylquinoline series of PDE4 inhibitors: Structure–activity relationship, optimization, and identification of a highly potent, well tolerated, PDE4 inhibitor

234

Discovery of a Substrate Selectivity Switch in Tyrosine Ammonia-Lyase, a Member of the Aromatic Amino Acid Lyase Family Original Research Article

235

Discovery of a sulfated tetrapeptide that binds to vascular endothelial growth factor

236

Discovery of a Thermophilic Protein Complex Stabilized by Topologically Interlinked Chains

237

Discovery of a Tight Brown Dwarf Companion to the Low-Mass Star LHS 2397a

238

Discovery of a Two-Component Monooxygenase SnoaW/SnoaL2 Involved in Nogalamycin Biosynthesis Original Research Article

239

Discovery of a very extended X-ray halo around a quiescent spiral galaxy – The “missing link” of galaxy formation

240

Discovery of a Wide, Low-Mass Binary System in Upper Scorpius

241

Discovery of a young asteroid cluster associated with P/2012 F5 (Gibbs)

242

Discovery of a z = 6.17 galaxy from CFHT and VLT observations

243

Discovery of A-770041, a src-family selective orally active lck inhibitor that prevents organ allograft rejection

244

Discovery of actinium, thorium, protactinium, and uranium isotopes

245

Discovery of active hydrothermal venting in Lake Taupo, New Zealand

246

Discovery of active site of vinblastine as application of nanotechnology in medicine

247

Discovery of active site of vinblastine as application of nanotechnology in medicine

248

Discovery of adamantane ethers as inhibitors of 11β-HSD-1: Synthesis and biological evaluation

249

Discovery of ADC absorption in the LMXB XB 1323-619 with XMM-Newton Original Research Article

250

Discovery of additional lead-rich stars

251

Discovery of agglutinated benthic foraminifera in Devonian black shales and their relevance for the redox state of ancient seas

252

Discovery of AICAR Tfase inhibitors that disrupt requisite enzyme dimerization

253

Discovery of alcohol dehydrogenase from mushrooms and application to alcoholic beverages

254

Discovery of amide and heteroaryl isosteres as carbamate replacements in a series of orally active γ-secretase inhibitors

255

Discovery of amido-benzisoxazoles as potent c-Kit inhibitors

256

Discovery of amino acid amides as new substrates for α-amino-ɛ-caprolactam racemase from Achromobacter obae

257

Discovery of amino-acetonitrile derivatives, a new class of synthetic anthelmintic compounds

258

Discovery of aminoquinolines as a new class of potent inhibitors of heat shock protein 90 (Hsp90): Synthesis, biology, and molecular modeling Original Research Article

259

Discovery of an adakite-like pluton near Dongqiyishan (Beishan, NW China) — Its age and tectonic significance

260

Discovery of an alkaline orthogneiss in the eclogite-bearing Cellier Unit (Champtoceaux Complex, Armorican Massif): a new witness of the Ordovician rifting

261

DISCOVERY OF AN ALTERNATIVELY SPLICED FORM OF BRAIN NATRIURETIC PEPTIDE: CHARACTERIZATION AND FUNCTION

262

Discovery of an androgen receptor modulator pharmacophore based on 2-quinolinones

263

Discovery of an archaic Homo sapiens skullcap in Northeast Mongolia

264

Discovery of an Aurora kinase inhibitor through site-specific dynamic combinatorial chemistry

265

Discovery of an Autunian macroflora and lithostratigraphic re-investigation on the western border of the Lodève Permian basin (Mont Sénégra, Hérault, France). Paleoenvironmental implications

266

Discovery of an endophytic alga in Ginkgo biloba

267

Discovery of an exceptionally potent and selective class of fatty acid amide hydrolase inhibitors enlisting proteome-wide selectivity screening: concurrent optimization of enzyme inhibitor potency and selectivity

268

Discovery of an ice cave in the Yatude Valley, Langhovde, Dronning Maud Land, East Antarctica

269

Discovery of an imidazopyridine-containing 1,4-benzodiazepine nonpeptide vitronectin receptor (αvβ3) antagonist with efficacy in a restenosis model

270

Discovery of an in situ carbocationic system using trityl chloride as a homogeneous organocatalyst for the solvent-free condensation of β-naphthol with aldehydes and amides/thioamides/alkyl carbamates in neutral media

271

Discovery of an Iron-Regulated Citrate Synthase in Staphylococcus aureus Original Research Article

272

Discovery of an M4 Spectroscopic Binary in Upper Scorpius: A Calibration Point for Young Low-Mass Evolutionary Models

273

Discovery of an N-(2-aminopyridin-4-ylmethyl)nicotinamide derivative: a potent and orally bioavailable NCX inhibitor Original Research Article

274

Discovery of an Optically Faint Quasar at z = 5.70 and Implications for the Faint Endof the Quasar Luminosity Function

275

Discovery of an orally bioavailable alkyl oxadiazole β3 adrenergic receptor agonist

276

Discovery of an orally efficaceous 4-phenoxypyrrolidine-based BACE-1 inhibitor

277

Discovery of an outcropping Mass Transport Deposit (MTD) in the Palaeogene subalpine synclines of southeastern France: Implications on flexural sub-basin deformation

278

Discovery of an Ultracool Subdwarf: LSR 1425+7102, the First Star with Spectral Type sdM8.0

279

Discovery of an Upper Miocene Vertebrate fauna near Tizi N’Tadderht, Skoura, Ouarzazate Basin (Central High Atlas, Morocco)

280

Discovery of Antagonist Peptides against Bacterial Helicase-Primase Interaction in B. stearothermophilus by Reverse Yeast Three-Hybrid Original Research Article

281

Discovery of Antagonists of PqsR, a Key Player in 2-Alkyl-4-quinolone-Dependent Quorum Sensing in Pseudomonas aeruginosa Original Research Article

282

Discovery of anticonvulsant activity of abietic acid through application of linear discriminant analysis

283

Discovery of anti-influenza A virus activity of a corynanthe-type indole alkaloid, hirsutine, in vitro and the structure-activity relationship of natural and synthetic analogs

284

Discovery of antirhinoviral leads by screening a combinatorial library of ureas prepared using covalent scavengers

285

Discovery of Archaean crust within the Akitkan orogenic belt of the Siberian craton: New insight into its architecture and history

286

Discovery of azetidinone acids as conformationally-constrained dual PPARα/γ agonists

287

Discovery of Baeyer–Villiger monooxygenases from photosynthetic eukaryotes

288

Discovery of benzamide tetrahydro-4H-carbazol-4-ones as novel small molecule inhibitors of Hsp90

289

Discovery of benzo[g]indol-3-carboxylates as potent inhibitors of microsomal prostaglandin E2 synthase-1 Original Research Article

290

Discovery of benzoylpiperazines as a novel class of potent and selective GlyT1 inhibitors

291

Discovery of betamethasone 17α-carbamates as dissociated glucocorticoid receptor modulators in the rat Original Research Article

292

Discovery of Bioactive Small-Molecule Inhibitor of Poly ADP-Ribose Polymerase: Implications for Energy-Deficient Cells Original Research Article

293

Discovery of bitriazolyl compounds as novel antiviral candidates for combating the tobacco mosaic virus

294

Discovery of brain penetrant, soluble, pyrazole amide EP1 receptor antagonists

295

Discovery of cancer biomarkers through the use of mouse models

296

Discovery of candidate phospholipid biomarkers in human lipoproteins with coronary artery disease by flow field-flow fractionation and nanoflow liquid chromatography–tandem mass spectrometry

297

Discovery of carboxypeptidase Y as a catalyst for the incorporation of sterically demanding α-fluoroalkyl amino acids into peptides

298

Discovery of cesium, lanthanum, praseodymium and promethium isotopes

299

Discovery of CH4-rich high-pressure fluid inclusions hosted in analcime from Dongying depression, China

300

Discovery of chromium, manganese, nickel, and copper isotopes

301

Discovery of classes among deep level centers in gallium arsenide

302

Discovery of co2 ice and leading–trailing spectral asymmetry on the uranian satellite ariel

303

Discovery of conformationally rigid 3-azabicyclo[3.1.0]hexane-derived dipeptidyl peptidase-IV inhibitors

304

Discovery of Conserved and Novel MicroRNAs in Galdieria sulphuraria

305

Discovery of Conserved Sequence Patterns Using a Stochastic Dictionary Model

306

Discovery of coumarin as the predominant allelochemical in Gliricidia sepium

307

Discovery of CP-199,330 and CP-199,331: Two potent and orally efficacious cysteinyl LT1 receptor antagonists devoid of liver toxicity

308

Discovery of cubic diamond and sp2 carbon micro-particles in “Chelyabinsk” meteorite by Raman micro-mapping

309

Discovery of cyclopentane- and cyclohexane-trans-1,3-diamines as potent melanin-concentrating hormone receptor 1 antagonists

310

Discovery of diacylphloroglucinols as a new class of GPR40 (FFAR1) agonists

311

Discovery of diaminobutane derivatives as Ca2+-permeable AMPA receptor antagonists Original Research Article

312

Discovery of dihydroquinoxalinone acetamides containing bicyclic amines as potent Bradykinin B1 receptor antagonists

313

Discovery of diphenylcarbamate derivatives as highly potent and selective IP receptor agonists: Orally active prostacyclin mimetics. Part 3

314

Discovery of dipolar-glassy state in a newly found solid–solution system of C5NH6(BF4)1−x(PF6)x

315

Discovery of direct inhibitor of KRAS oncogenic protein by natural products: a combination of pharmacophore search, molecular docking, and molecular dynamic studies

316

Discovery of distyly in Narcissus (Amaryllidaceae)

317

Discovery of dividing neurons in human brains excites researchers

318

Discovery of doubly-magic 48Ni at GANIL Original Research Article

319

Discovery of Drug-Resistant and Drug-Sensitizing Mutations in the Oncogenic PI3K Isoform p110α

320

Discovery of Dual Inhibitors of the Immune Cell PI3Ks p110δ and p110γ: a Prototype for New Anti-inflammatory Drugs Original Research Article

321

Discovery of dysprosium, holmium, erbium, thulium, and ytterbium isotopes

322

Discovery of Early Optical Emission from GRB 021211

323

Discovery of Early Paleozoic eclogite from the East Kunlun, Western China and its tectonic significance

324

Discovery of effective solvents for platelet-type graphite nanofibers Original Research Article

325

Discovery of Erysiphe platani anamorph on Platanus × hispanica from Brazil

326

Discovery of factors influencing citation impact based on a soft fuzzy rough set model

327

Discovery of factors influencing patent value based on machine learning in patents in the field of nanotechnology

328

Discovery of feature-based hot spots using supervised clustering

329

Discovery of FK453, a novel non-xanthine adenosine A1 receptor antagonist

330

Discovery of FR115092 : A novel antinephritic agent

331

Discovery of FR166124, a novel water-soluble pyrazolo-[1,5-α]pyridine adenosine A1 receptor antagonist

332

Discovery of functional protein groups by clustering community links and integration of ontological knowledge

333

Discovery of fuzzy quantitative sequential patterns with multiple minimum supports and adjustable membership functions

334

Discovery of galectin ligands in fully randomized combinatorial one-bead-one-compound (glyco)peptide libraries

335

Discovery of gallium, germanium, lutetium, and hafnium isotopes

336

Discovery of GS-9131: Design, synthesis and optimization of amidate prodrugs of the novel nucleoside phosphonate HIV reverse transcriptase (RT) inhibitor GS-9148 Original Research Article

337

Discovery of Habritys brevicornis (Ratzeburg, 1844) (Hymenoptera: Pteromalidae) in the Middle-East

338

Discovery of halogenated eurypamide B analogues as inhibitors of lipid droplet accumulation in macrophages

339

Discovery of hazardous foreign bodies observed during anesthetic practice

340

Discovery of Helicobacter pylori shikimate kinase inhibitors: Bioassay and molecular modeling Original Research Article

341

Discovery of heteroaryl sulfonamides as new EP1 receptor selective antagonists Original Research Article

342

Discovery of heterobicyclic templates for novel metabotropic glutamate receptor subtype 5 antagonists

343

Discovery of heterocyclic ureas as a new class of raf kinase inhibitors: identification of a second generation lead by a combinatorial chemistry approach

344

Discovery of hexacoordinate hypervalent carbon compounds: Density functional study

345

Discovery of Hg–Cu-bearing metal-sulfide assemblages in a primitive H-3 chondrite: Towards a new insight in early solar system processes

346

Discovery of hidden correlations in a local transaction database based on differences of correlations

347

Discovery of high utility itemsets from on-shelf time periods of products

348

Discovery of highly potent and selective benzyloxybenzyl-based peroxisome proliferator-activator receptor (PPAR) δ agonists

349

Discovery of highly potent Src SH2 binders: Structure–activity studies and X-ray structures

350

Discovery of highly potent, selective, orally bioavailable, metabotropic glutamate subtype 5 (mGlu5) receptor antagonists devoid of cytochrome P450 1A2 inhibitory activity

351

Discovery of highly selective EP4 receptor agonists that stimulate new bone formation and restore bone mass in ovariectomized rats

352

Discovery of high-pressure granulite-facies metamorphism in northern Vietnam: Constraints on the Permo-Triassic Indochinese continental collision tectonics

353

Discovery of historical Tainan: a digital approach

354

Discovery of Holocene millennial climate cycles in the Asian continental interior: Has the sun been governing the continental climate?

355

Discovery of human CCR5 antagonists containing hydantoins for the treatment of HIV-1 infection

356

Discovery of human zinc deficiency: 50 years later

357

Discovery of human zinc deficiency: impact on human health

358

Discovery of hydrometeorological patterns

359

Discovery of hydrothermal sulfide mineralization from southern Kermadec arc volcanoes (SW Pacific)

360

Discovery of hydroxamic acid analogs as dual inhibitors of phosphodiesterase-1 and -5

361

Discovery of imidazo[1,2-c]pyrimidin-5(6H)-one heterosubstituted nucleoside analogues with potent activity against human hepatitis B virus in

362

Discovery of imidazole carboxamides as potent and selective CCK1R agonists

363

Discovery of imidazole glycerol phosphate dehydratase inhibitors through 3-D database searching

364

Discovery of imidazole vinyl pyrimidines as a novel class of kinase inhibitors which inhibit Tie-2 and are orally bioavailable

365

Discovery of imidazolidine-2,4-dione-linked HIV protease inhibitors with activity against lopinavir-resistant mutant HIV Original Research Article

366

Discovery of Iminobenzimidazole Derivatives as Novel Cytotoxic Agents

367

Discovery of immune molecules and their crucial functions in shrimp immunity

368

Discovery of Improved EGF Agonists Using a Novel In Vitro Screening Platform

369

Discovery of impurities existing state in carbide slag by chemical dissociation

370

Discovery of indenopyrazoles as EGFR and VEGFR-2 tyrosine kinase inhibitors by in silico high-throughput screening

371

Discovery of Independence: South Asia at 63

372

Discovery of indole-containing tetracycles as a new scaffold for androgen receptor ligands

373

Discovery of inhibitors of brassinin oxidase based on the scaffolds of the phytoalexins brassilexin and wasalexin Original Research Article

374

Discovery of inhibitors of human adipocyte fatty acid-binding protein, a potential type 2 diabetes target

375

Discovery of inhibitors of the channel-activating protease prostasin (CAP1/PRSS8) utilizing structure-based design

376

Discovery of inhibitors of the pentein superfamily protein dimethylarginine dimethylaminohydrolase (DDAH), by virtual screening and hit analysis

377

Discovery of Inhibitors that Elucidate the Role of UCH-L1 Activity in the H1299 Lung Cancer Cell Line Original Research Article

378

Discovery of insect parasitism and subsequent development of parasitoid research in Japan

379

Discovery of invisible extra fronts in single-component frontal analysis in liquid chromatography

380

Discovery of iridium and other element anomalies near the 1908 Tunguska explosion site

381

Discovery of IRL 3461: a novel and potent endothelin antagonist with balanced ETA/ETB affinity

382

Discovery of iron-K absorption lines from the transient jets GRS 1915+105 and GRO J1655-40 Original Research Article

383

Discovery of isotopes of elements with

384

Discovery of isotopes of the transuranium elements with 93≤Z≤98

385

Discovery of isotopes with

386

Discovery of isoxazolinone antibacterial agents. Nitrogen as a replacement for the stereogenic center found in oxazolidinone antibacterials

387

Discovery of Jadeite-Jade in Guatemala Confirmed by Non-Destructive Raman Microscopy

388

Discovery of jarosite within the Mawrth Vallis region of Mars: Implications for the geologic history of the region

389

Discovery of jet quenching and beyond Original Research Article

390

Discovery of jet quenching at RHIC and the opacity of the produced gluon plasma Original Research Article

391

Discovery of Kibdelomycin, A Potent New Class of Bacterial Type II Topoisomerase Inhibitor by Chemical-Genetic Profiling in Staphylococcus aureus Original Research Article

392

Discovery of Kilohertz Quasi-periodic Oscillations and Shifted Frequency Correlations in the Accreting Millisecond Pulsar XTE J1807294

393

Discovery of L-740,515, a potent thienopyridine cysLT1 receptor (LTD4 receptor) antagonist

394

Discovery of L-755,507: A subnanomolar human β3 adrenergic receptor agonist

395

Discovery of L-791,943: A potent, selective, non emetic and orally active phosphodiesterase-4 inhibitor

396

Discovery of Latest Devonian/Earliest Mississippian microfossils in San Salvador Patlanoaya (Puebla, Mexico); biogeographic and geodynamic consequences

397

Discovery of LB30057, a benzamidrazone-based selective oral thrombin inhibitor

398

Discovery of long-acting N-(cyanomethyl)-N-alkyl-l-prolinamide inhibitors of dipeptidyl peptidase IV Original Research Article

399

Discovery of low mucus adhesion surfaces

400

Discovery of low nanomolar non-hydroxamate inhibitors of tumor necrosis factor-α converting enzyme (TACE)

401

Discovery of magnetic field variations with the 12.1-minute pulsation period of the roAp star (gamma) Equulei

402

Discovery of male of Proconura persica Delvare (Hymenoptera: Chalcididae), recently described from Iran

403

Discovery of mass spectral characteristics and automatic identification of wax esters from gas chromatography mass spectrometry data

404

Discovery of maximum length frequent itemsets

405

Discovery of melanin-concentrating hormone receptor R1 antagonists using high-throughput synthesis Original Research Article

406

Discovery of Messinian canyons and new seismic stratigraphic model, offshore Provence (SE France): Implications for the hydrographic network reconstruction

407

Discovery of metastable tetragonal disordered phase upon phase transitions in the equiatomic nanostructured FePd alloy Original Research Article

408

Discovery of micromolar PDE IV inhibitors that exhibit much reduced affinity for the [3H]rolipram binding site: 3-norbornyloxy-4-methoxyphenylmethylene oxindoles

409

Discovery of microscopic evidence for shock metamorphism at the Serpent Mound structure, south-central Ohio: confirmation of an origin by impact

410

Discovery of Middle Jurassic (Bajocian) Radiolaria from the sedimentary cover of the Vedi ophiolite (Lesser Caucasus, Armenia)

411

Discovery of Miocene adakitic dacite from the Eastern Pontides Belt (NE Turkey) and a revised geodynamic model for the late Cenozoic evolution of the Eastern Mediterranean region

412

Discovery of MK-0476, a potent and orally active leukotriene D4 receptor antagonist devoid of peroxisomal enxyme induction

413

Discovery of N-(2-aryl-cyclohexyl) substituted spiropiperidines as a novel class of GlyT1 inhibitors

414

Discovery of N-(2-hydroxy-2-aryl-cyclohexyl) substituted spiropiperidines as GlyT1 antagonists with improved pharmacological profile

415

Discovery of N-[(3R,5R)-1-azabicyclo[3.2.1]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide as an agonist of the α7 nicotinic acetylcholine receptor: In vitro and in vivo activity

416

Discovery of narrow X-ray absorption features from the low-mass X-ray binary X 1254-690 with XMM-Newton

417

Discovery of neurosteroid glucuronides in mouse brain Original Research Article

418

Discovery of new angiotensin converting enzyme (ACE) inhibitors from medicinal plants to treat hypertension using an in vitro assay

419

Discovery of new binding elements in DPP-4 inhibition and their applications in novel DPP-4 inhibitor design

420

Discovery of New Bioactive Secondary Metabolites from Psychrophilic Microorganisms — Mini Review

421

Discovery of new C3aR ligands. Part 1: Arginine derivatives

422

Discovery of new C3aR ligands. Part 2: Amino-piperidine derivatives

423

Discovery of new catalytic materials for the water–gas shift reaction by high-throughput experimentation Original Research Article

424

Discovery of new chemical leads for prostaglandin D2 receptor antagonists

425

Discovery of new chemical leads for selective EP1 receptor antagonists Original Research Article

426

Discovery of new diphenyloxazole derivatives containing a pyrrolidine ring: Orally active prostacyclin mimetics. Part 2

427

Discovery of New Drugs Against Tuberculosis: History Guides

428

Discovery of new fuel-lean NO reduction catalyst leads using combinatorial methodologies

429

Discovery of new Gram-negative antivirulence drugs: Structure and properties of novel E. coli WaaC inhibitors

430

Discovery of new hydrothermal vent sites in Bransfield Strait, Antarctica

431

Discovery of new hydrothermal vent sites in Bransfield Strait, Antarctica

432

Discovery of new inhibitors of aldose reductase from molecular docking and database screening Original Research Article

433

Discovery of new Milky Way star cluster candidates in the 2MASS Point Source Catalog. II. Physical properties of the star cluster CC 01

434

Discovery of new MurF inhibitors via pharmacophore modeling and QSAR analysis followed by in-silico screening Original Research Article

435

Discovery of new paraffin isomerization catalysts based on SO42−/ZrO2 and WOx/ZrO2 applying combinatorial techniques

436

Discovery of new peptide-Based catalysts for the direct asymmetric aldol reaction

437

Discovery of new phase and analysis of phase relationships in BaBiO3 with thermal analyses

438

Discovery of new pyridoacridine alkaloids from Lissoclinum cf. badium that inhibit the ubiquitin ligase activity of Hdm2 and stabilize p53 Original Research Article

439

Discovery of new small molecules that influence neuroblast cell migration from the subventricular zone

440

Discovery of N-Hydroxy-2-(2-oxo-3-pyrrolidinyl)acetamides as potent and selective inhibitors of tumor necrosis factor-α converting enzyme (TACE)

441

Discovery of non-A, non-B hepatitis and identification of its etiology

442

Discovery of non-carbohydrate inhibitors of aminoglycoside-modifying enzymes Original Research Article

443

Discovery of non-covalent dipeptidyl peptidase IV inhibitors which induce a conformational change in the active site

444

Discovery of non-peptidic P2–P3 butanediamide renin inhibitors with high oral efficacy Original Research Article

445

Discovery of nonsteroidal glucocorticoid receptor ligands based on 6-indole-1,2,3,4-tetrahydroquinolines

446

Discovery of non-steroidal mifepristone mimetics: Pyrazoline-based PR antagonists

447

Discovery of non-Zwitterionic GABAA receptor full agonists and a superagonist

448

Discovery of novel 1,2,3,4-tetrahydroisoquinolines and 3,4-dihydroisoquinoline-1(2H)-ones as potent and selective inhibitors of KDR: Synthesis, SAR, and pharmacokinetic properties

449

Discovery of Novel 1,2,3-Triazole Analogues as Anti-Tuberculosis agents Using 3D QSAR, Molecular Docking, and In Silico ADMET Screening

450

Discovery of novel 1-arylmethyl pyrrolidin-2-yl ethanol amines as calcium-sensing receptor antagonists

451

Discovery of novel 2-(aminoheteroaryl)-thiazole-5-carboxamides as potent and orally active Src-family kinase p56Lck inhibitors

452

Discovery of novel 2,3-diarylfuro[2,3-b]pyridin-4-amines as potent and selective inhibitors of Lck: Synthesis, SAR, and pharmacokinetic properties

453

Discovery of novel 4-amino-6-arylaminopyrimidine-5-carbaldehyde oximes as dual inhibitors of EGFR and ErbB-2 protein tyrosine kinases

454

Discovery of novel 8-azoniabicyclo[3.2.1]octane carbamates as muscarinic acetylcholine receptor antagonists

455

Discovery of novel and orally active NR2B-selective N-methyl-d-aspartate (NMDA) antagonists, pyridinol derivatives with reduced HERG binding affinity

456

Discovery of novel and potent aryl diamines as leukotriene A4 hydrolase inhibitors

457

Discovery of novel and selective IKK-β serine-threonine protein kinase inhibitors. Part 1

458

Discovery of novel and selective tertiary alcohol containing inhibitors of the norepinephrine transporter

459

Discovery of novel aspartyl ketone dipeptides as potent and selective caspase-3 inhibitors

460

Discovery of novel benzimidazolones as potent non-nucleoside reverse transcriptase inhibitors active against wild-type and mutant HIV-1 strains

461

Discovery of novel benzothiazolesulfonamides as potent inhibitors of HIV-1 protease Original Research Article

462

Discovery of novel biaryl heterocyclic EP1 receptor antagonists

463

Discovery of novel conformationally constrained tropane-based biaryl and arylacetylene ligands as potent and selective norepinephrine transporter inhibitors and potential antidepressants

464

Discovery of novel conformationally restricted diazocan peptidomimetics as inhibitors of interleukin-1β synthesis

465

Discovery of novel dialkyl substituted thiophene inhibitors of HCV by in silico screening of the NS5B RdRp

466

Discovery of novel dual functional agent as PPARγ agonist and 11β-HSD1 inhibitor for the treatment of diabetes Original Research Article

467

Discovery of novel FMS kinase inhibitors as anti-inflammatory agents

468

Discovery of Novel Glucagon Receptor Antagonists Using Combined Pharmacophore Modeling and Docking

469

Discovery of novel heteroaryl-substituted chalcones as inhibitors of TNF-α-induced VCAM-1 expression

470

Discovery of novel heterocyclic factor VIIa inhibitors

471

Discovery of novel homogeneous rare earth catalysts by IR-thermography: epoxide opening with alcohols and Baeyer–Villiger oxidations with hydrogen peroxide Original Research Article

472

Discovery of novel hydantoins as selective non-hydroxamate inhibitors of tumor necrosis factor-α converting enzyme (TACE)

473

Discovery of novel hydroxamates as highly potent tumor necrosis factor-α converting enzyme inhibitors. Part II: Optimization of the S3′ pocket

474

Discovery of novel hydroxy pyrazole based factor IXa inhibitor

475

Discovery of novel hydroxy-thiazoles as HIF-α prolyl hydroxylase inhibitors: SAR, synthesis, and modeling evaluation

476

Discovery of novel indazole-linked triazoles as antifungal agents

477

Discovery of novel inhibitors of 11β-hydroxysteroid dehydrogenase type 1 by docking and pharmacophore modeling

478

Discovery of novel inhibitors of ghrelin O-acyltransferase enzyme: an in-silico approach

479

Discovery of novel isatin-based thiosemicarbazones: synthesis, antibacterial, antifungal, and antimycobacterial screening

480

Discovery of novel isothiazole inhibitors of the TrkA kinase: Structure–activity relationship, computer modeling, optimization, and identification of highly potent antagonists

481

Discovery of novel isoxazolines as anti-tuberculosis agents

482

Discovery of novel low molecular weight inhibitors of IMPDH via virtual needle screening

483

Discovery of Novel Mastitis-Related SNP and RNA Splicing on HSF1 Gene in Chinese Holstein Cattle

484

Discovery of novel modulators of metabotropic glutamate receptor subtype-5 Original Research Article

485

Discovery of novel neuronal voltage-Dependent calcium channel blockers based on emopamil left hand as a bioactive template

486

Discovery of novel non-cytotoxic salicylhydrazide containing HIV-1 integrase inhibitors

487

Discovery of novel nonpeptide tricyclic inhibitors of ras farnesyl protein transferase Original Research Article

488

Discovery of novel non-peptidic ketopiperazine-based renin inhibitors Original Research Article

489

Discovery of novel nonsteroidal glucocorticoid receptor modulators

490

Discovery of novel orally active ureido NPY Y5 receptor antagonists

491

Discovery of Novel Peptidomimetics for Brain-Derived Neurotrophic Factor using Phage Display Technology

492

Discovery of Novel Phosphonic Acid Derivatives as New Chemical Leads for Inhibitors of TNF-α production Original Research Article

493

Discovery of novel phosphorus-containing steroids as selective glucocorticoid receptor antagonist

494

Discovery of novel potent and selective dipeptide hepatitis C virus NS3/4A serine protease inhibitors

495

Discovery of novel PRL-3 inhibitors based on the structure-based virtual screening

496

Discovery of novel prostaglandin analogs of PGE2 as potent and selective EP2 and EP4 receptor agonists

497

Discovery of novel PTP1b inhibitors

498

Discovery of novel purine derivatives with potent and selective inhibitory activity against c-Src tyrosine kinase Original Research Article

499

Discovery of novel series of benzoic acid derivatives containing biphenyl ether moiety as potent and selective human β3-adrenergic receptor agonists: Part IV

500

Discovery of novel sesquiterpenoids from a gorgonian Menella sp.

501

Discovery of novel tetrahydroisoquinoline derivatives as potent and selective factor Xa inhibitors

502

Discovery of novel thieno[2,3-d]pyrimidin-4-yl hydrazone-based inhibitors of Cyclin D1-CDK4: Synthesis, biological evaluation and structure–activity relationships. Part 2 Original Research Article

503

Discovery of novel thiourea derivatives as potent and selective β3-adrenergic receptor agonists Original Research Article

504

Discovery of novel trans-3,5-disubstituted pyrrolidinylthio-1β-methylcarbapenems Original Research Article

505

Discovery of Novel Transcriptional and Epigenetic Targets in APL by Global ChIP Analyses: Emerging Opportunity and Challenge

506

Discovery of novel α-glucosidase inhibitors based on the virtual screening with the homology-modeled protein structure Original Research Article

507

Discovery of novel, non-acidic 1,5-biaryl pyrrole EP1 receptor antagonists

508

Discovery of novel, orally active dual NK1/NK2 antagonists

509

Discovery of novel, potent and bioavailable proline-urea based macrocyclic HCV NS3/4A protease inhibitors

510

Discovery of novel, potent, and orally active spiro-urea human glucagon receptor antagonists

511

Discovery of N-phenyl nicotinamides as potent inhibitors of Kdr

512

Discovery of N-propylurea 3-benzylpiperidines as selective CC chemokine receptor-3 (CCR3) antagonists

513

Discovery of Nuclear DNA-like RNA (dRNA, hnRNA) and Ribonucleoproteins Particles Containing hnRNA

514

Discovery of Opisthorchis viverrini metacercariae in freshwater fish in southern Cambodia

515

Discovery of orally active butyrolactam 11β-HSD1 inhibitors

516

Discovery of orally active prostaglandin D2 receptor antagonists

517

Discovery of orally active pyrrolopyridine- and aminopyridine-based Met kinase inhibitors

518

Discovery of orally available spirodiketopiperazine-based CCR5 antagonists Original Research Article

519

Discovery of orally bioavailable and novel urea agonists of the high affinity niacin receptor GPR109A

520

Discovery of orally bioavailable NK1 receptor antagonists

521

Discovery of osteoblast-associated genes using cDNA microarrays

522

Discovery of OT4003, a novel, potent, and orally active cys-LT1 receptor antagonist Original Research Article

523

Discovery of Oxysterol-Derived Pharmacological Chaperones for NPC1: Implication for the Existence of Second Sterol-Binding Site Original Research Article

524

Discovery of palladium, antimony, tellurium, iodine, and xenon isotopes

525

Discovery of para-alkylthiophenoxyacetic acids as a novel series of potent and selective PPARδ agonists

526

Discovery of Peptoid Ligands for Anti-Aquaporin 4 Antibodies Original Research Article

527

Discovery of Permian sporopollen from Daftar, Taxkorgan, Xinjiang and their geological implications

528

Discovery of phenyl alanine derived ketoamides carrying benzoyl residues as novel calpain inhibitors

529

Discovery of Picomolar Slow Tight-Binding Inhibitors of α-Fucosidase

530

Discovery of Picomolar Slow Tight-Binding Inhibitors of α-Fucosidase Original Research Article

531

Discovery of pinoresinol reductase genes in sphingomonads

532

Discovery of piperazinylimidazo[1,2-a]pyridines as novel S4 binding elements for orally active Factor Xa inhibitors Original Research Article

533

Discovery of piperidine carboxamide TRPV1 antagonists

534

Discovery of piperidine-aryl urea-based stearoyl-CoA desaturase 1 inhibitors

535

Discovery of platelet-type 12-human lipoxygenase selective inhibitors by high-throughput screening of structurally diverse libraries Original Research Article

536

Discovery of platelet-type 12-human lipoxygenase selective inhibitors by high-throughput screening of structurally diverse libraries Original Research Article

537

Discovery of potent and cell-active allosteric dual Akt 1 and 2 inhibitors

538

Discovery of potent and orally active MTP inhibitors as potential anti-obesity agents

539

Discovery of potent and orally active tricyclic-based FBPase inhibitors Original Research Article

540

Discovery of potent and orally bioavailable heterocycle-based β3-adrenergic receptor agonists, potential therapeutics for the treatment of obesity

541

Discovery of potent and orally bioavailable N,N′-diarylurea antagonists for the CXCR2 chemokine receptor

542

Discovery of Potent and Reversible Monoacylglycerol Lipase Inhibitors Original Research Article

543

Discovery of Potent and Selective Covalent Inhibitors of JNK Original Research Article

544

Discovery of potent and selective inhibitors of 11β-HSD1 for the treatment of metabolic syndrome

545

Discovery of potent and selective orally bioavailable β-substituted phenylalanine derived dipeptidyl peptidase IV inhibitors

546

Discovery of potent and selective PARP-1 and PARP-2 inhibitors: SBDD analysis via a combination of X-ray structural study and homology modeling Original Research Article

547

Discovery of potent and selective phenylalanine based dipeptidyl peptidase IV inhibitors

548

Discovery of potent and selective phenylalanine derived CCR3 antagonists. Part 1

549

Discovery of potent and selective phenylalanine derived CCR3 receptor antagonists. Part 2

550

Discovery of potent and selective PKC-θ inhibitors

551

Discovery of potent and selective small molecule NPY Y5 receptor antagonists

552

Discovery of potent and selective succinyl hydroxamate inhibitors of matrix metalloprotease-3 (Stromelysin-1)

553

Discovery of potent and selective β-homophenylalanine based dipeptidyl peptidase IV inhibitors

554

Discovery of potent and stable conformationally constrained analogues of the MCH R1 antagonist SB-568849

555

Discovery of potent and use-dependent sodium channel blockers for treatment of chronic pain

556

Discovery of potent BACE-1 inhibitors containing a new hydroxyethylene (HE) Scaffold: Exploration of P1′ alkoxy residues and an aminoethylene (AE) central core Original Research Article

557

Discovery of potent cholecystokinin-2 receptor antagonists: Elucidation of key pharmacophore elements by X-ray crystallographic and NMR conformational analysis Original Research Article

558

Discovery of potent CRTh2 (DP2) receptor antagonists

559

Discovery of potent furan piperazine sodium channel blockers for treatment of neuropathic pain Original Research Article

560

Discovery of potent HIV-1 protease inhibitors incorporating sulfoximine functionality

561

Discovery of potent imidazole and cyanophenyl containing farnesyltransferase inhibitors with improved oral bioavailability

562

Discovery of potent inhibitors of pseudomonal quorum sensing via pharmacophore modeling and in silico screening

563

Discovery of potent LPA2 (EDG4) antagonists as potential anticancer agents

564

Discovery of potent pyrrolidone-based HIV-1 protease inhibitors with enhanced drug-like properties

565

Discovery of potent sulfonamide P4-capped ketoamide second generation inhibitors of hepatitis C virus NS3 serine protease with favorable pharmacokinetic profiles in preclinical species Original Research Article

566

Discovery of potent thiosemicarbazone inhibitors of rhodesain and cruzain

567

Discovery of potent T-type calcium channel blocker

568

Discovery of potent, efficacious, and orally bioavailable inhibitors of blood coagulation factor Xa with neutral P1 moieties

569

Discovery of potent, orally active benzimidazole glucagon receptor antagonists

570

Discovery of potent, selective 4-fluoroproline-based thrombin inhibitors with improved metabolic stability Original Research Article

571

Discovery of potent, selective human granzyme B inhibitors that inhibit CTL mediated apoptosis

572

Discovery of potent, selective, and orally bioavailable oxadiazole-based dipeptidyl peptidase IV inhibitors

573

Discovery of potent, selective, and orally bioavailable pyridone-based dipeptidyl peptidase-4 inhibitors

574

Discovery of Potential Natural Dipeptidyl Peptidase-4 Inhibitors for Type-2 Diabetes Treatment via Structure-Based Virtual Screening

575

Discovery of predictive rule sets for chlorophyll-a dynamics in the Nakdong River (Korea) by means of the hybrid evolutionary algorithm HEA

576

Discovery of probable Tunguska cosmic body material: anomalies of platinum group elements and rare-earth elements in peat near the Explosion Site (1908)

577

Discovery of Prognostic Signature Genes for Overall Survival Prediction in Gastric Cancer

578

Discovery of protein–protein binding disruptors using multi-component condensations small molecules

579

Discovery of proteins related to coronary artery disease using industrial-scale proteomics analysis of pooled plasma

580

Discovery of Pseudofrenelopsis from the Lower Cretaceous of Liupanshan Basin and its paleoclimatic significance

581

Discovery of pyrazine carboxamide CB1 antagonists: The introduction of a hydroxyl group improves the pharmaceutical properties and in vivo efficacy of the series

582

Discovery of pyrazolopyrimidines as the first class of allosteric agonists for the high affinity nicotinic acid receptor GPR109A

583

Discovery of pyridone-containing imidazolines as potent and selective inhibitors of neuropeptide Y Y5 receptor Original Research Article

584

Discovery of pyrimidine benzimidazoles as Lck inhibitors: Part I

585

Discovery of pyrrole-based hepatoselective ligands as potent inhibitors of HMG-CoA reductase Original Research Article

586

Discovery of quinazolines as a novel structural class of potent inhibitors of NF-κB activation Original Research Article

587

Discovery of radiolaria and conodonts in the Carboniferous–Permian of San Salvador Patlanoaya (Puebla, Mexico); biostratigraphic implications

588

Discovery of radiolaria from Upper Cretaceous Oceanic Red Beds in Daba, Kangmar and its paleogeographic implication

589

Discovery of recurrent multiple brain states in non-convulsive status epilepticus

590

Discovery of Ro 48-5695: A potent mixed endothelin receptor antagonist optimized from bosentan

591

Discovery of rubidium, strontium, molybdenum, and rhodium isotopes

592

Discovery of safety biomarkers for atorvastatin in rat urine using mass spectrometry based metabolomics combined with global and targeted approach Original Research Article

593

Discovery of samarium, europium, gadolinium, and terbium isotopes

594

Discovery of sapphirine-bearing Mg–Al granulites in the North China Craton: Implications for Paleoproterozoic ultrahigh temperature metamorphism

595

Discovery of SB-705498: A potent, selective and orally bioavailable TRPV1 antagonist suitable for clinical development

596

Discovery of scandium, titanium, mercury, and einsteinium isotopes

597

Discovery of selective aldo-keto reductase ligands—an on-bead assay strategy

598

Discovery of selective and nonpeptidic cathepsin S inhibitors

599

Discovery of selective dopamine D3 ligands: I. Dimeric 2-[4-(3-aminopropoxy)phenyl]benzimidazole antagonists

600

Discovery of selective dopamine D3 ligands: II. 2-[4-[3-(4-aryl-1-piperazinyl)propoxy]phenyl]benzimidazole partial agonists

601

Discovery of selective dopamine D4 receptor antagonists: 1-Aryloxy-3-(4-aryloxypiperidinyl)-2-propanols

602

Discovery of selective hydroxamic acid inhibitors of tumor necrosis factor-α converting enzyme

603

Discovery of selective imidazole-based inhibitors of mammalian 15-lipoxygenase: Highly potent against human enzyme within a cellular environment

604

Discovery of selective metal-binding peptoids using 19F encoded combinatorial libraries

605

Discovery of selective phosphonamide-based inhibitors of tumor necrosis factor-α converting enzyme (TACE)

606

Discovery of selective, small-molecule inhibitors of RNA complexes—1. The tat protein/TAR RNA complexes required for HIV-1 transcription Original Research Article

607

Discovery of selective, small-molecule inhibitors of RNA complexes—II. Self-splicing group I intron ribozyme Original Research Article

608

Discovery of small molecule agonists for the bombesin receptor subtype 3 (BRS-3) based on an omeprazole lead

609

Discovery of small molecule antagonists of TRPV1

610

Discovery of small molecule benzimidazole antagonists of the chemokine receptor CXCR3

611

Discovery of small molecule inhibitors of integrin αvβ3 through structure-based virtual screening

612

Discovery of small-molecule inhibitors of tyrosinase

613

Discovery of soluble epoxide hydrolase inhibitors from natural products

614

Discovery of Specific Inhibitors of Human USP7/HAUSP Deubiquitinating Enzyme Original Research Article

615

Discovery of substituted 3,4-Diphenyl-thiazoles as a novel class of monoamine transporter inhibitors through 3-D pharmacophore search using a new pharmacophore model derived from mazindol

616

Discovery of substituted 8,9-dicarboxyldibenzo [2,3:5,6] bicyclo [5.2.0] nonan-4-ones with moderate binding affinity to the endothelin ETA and ETB receptors

617

Discovery of subtle effects in a human intervention trial through multilevel modeling

618

Discovery of subtype-selective NMDA receptor ligands: 4-Benzyl-1-piperidinylalkynylpyrroles, pyrazoles and imidazoles as NR1 /2B antagonists

619

Discovery of sulfonylalkylamides: A new class of orally active factor Xa inhibitors Original Research Article

620

Discovery of superoxide reductase: an historical perspective

621

Discovery of symmetry by voting method

622

Discovery of tantalum, rhenium, osmium, and iridium isotopes

623

Discovery of tertiary aminoacids as dual PPARα/γ agonists-I

624

Discovery of tetrahydro-β-carbolines as inhibitors of the mitotic kinesin KSP Original Research Article

625

Discovery of tetralin ureas as potent melanin concentrating hormone 1 receptor antagonists

626

Discovery of the arsenic isotopes

627

Discovery of the astatine, radon, francium, and radium isotopes

628

Discovery of the barium isotopes

629

Discovery of the bi-layered structure in spin-coated polyacrylamide films on the gold surface

630

Discovery of the cadmium isotopes

631

Discovery of the calcium, indium, tin, and platinum isotopes

632

Discovery of the catechol structural moiety as a Stat3 SH2 domain inhibitor by virtual screening

633

Discovery of the cerium isotopes

634

Discovery of the cobalt isotopes

635

Discovery of the connection among age-related macular degeneration, MTHFR C677T and PAI 1 4G/5G gene polymorphisms, and body mass index by means of Bayesian inference methods

636

Discovery of the content of rumination thoughts among women with marital conflicts: Qualitative study

637

Discovery of the cross-coupling reaction between Grignard reagents and C(sp2) halides catalyzed by nickel–phosphine complexes

638

Discovery of the Endocannabinoid System: A Breakthrough in Neuroscience

639

Discovery of the Eucalyptus canker pathogen Chrysoporthe cubensis on native Miconia (Melastomataceae) in Colombia

640

Discovery of the first antibacterial small molecule inhibitors of MurB

641

Discovery of the first non-planar flavonoid that can strongly inhibit xanthine oxidase: protoapigenone 1′-O-propargyl ether

642

Discovery of the first Quaternary maar in the Bohemian Massif, Central Europe, based on combined geophysical and geological surveys

643

Discovery of the first series of inhibitors of human papillomavirus type 11: inhibition of the assembly of the E1–E2–Origin DNA complex

644

Discovery of the genera Bolothrips Priesner, 1926 and Cephalothrips Uzel, 1895 (Thysanoptera: Phlaeothripidae) from the Oriental region

645

Discovery of the genus Cinetus Jurine, 1807 (Hymenoptera: Diapriidae) from Iran, with five species records

646

Discovery of the gold isotopes

647

Discovery of the hypothalamic gonadotropin-releasing hormone pulse generator and of its physiologic significance

648

Discovery of the iron isotopes

649

Discovery of the Isotopes with 11≤Z≤19

650

Discovery of the krypton isotopes

651

Discovery of the largest impact crater field on Earth in the Gilf Kebir region, Egypt

652

Discovery of the Life-Organizing Principle: In Search of the Fundamentals Laws of Life, E.M. Elsheik. iUniverse LLC, Bloomington, USA (2014)

653

Discovery of the Life-Organizing Principle: In Search of the Fundamentals Laws of Life, E.M. Elsheik. iUniverse LLC, Bloomington, USA (2014)

654

Discovery of the Low-Redshift Optical Afterglow of GRB 011121 and Its Progenitor Supernova SN 2001ke

655

Discovery of the male of the subterranean species niphargus ozimeci karaman, g., 2011 (fam. niphargidae) in bosnia Herzegovina (contribution to the knowledge of the amphipoda 262)

656

Discovery of the male of the subterranean species niphargus ozimeci karaman, g., 2011 (fam. niphargidae) in bosnia & Herzegovina (contribution to the knowledge of the amphipoda 262)

657

Discovery of the most rapidly-rotating, non-degenerate, magnetic massive star by the MiMeS collaboration

658

Discovery of the new proton emitter 144Tm

659

Discovery of the New Target for Identification of Mycobacterium tuberculosis

660

Discovery of the Ordovician Millbrig K-bentonite Bed in the Trenton Group of New York State: implications for regional correlation and sequence stratigraphy in eastern North America

661

Discovery of the Oriental genus Piyumoides Leclercq, 1963 (Hymenoptera, Crabronidae) in the Indian subcontinent with the description of a new species

662

Discovery of the Paleo-Tethys residual peridotites along the Anyemaqen–KunLun suture zone (North Tibet)

663

Discovery of the predatory mite Neoseiulus californicus (Acari: Phytoseiidae) in some rose greenhouses in Iran and describing variation in spermathecal calyx shape

664

Discovery of the rotational spectrum of the weakly bound complex CO–H2

665

Discovery of the silver isotopes

666

Discovery of the thallium, lead, bismuth, and polonium isotopes

667

Discovery of the tungsten carbonyl-catalyzed endo-selective alkynyl alcohol cycloisomerization reaction: applications to stereoselective syntheses of d-olivose, d-olivose disaccharide substructures of landomycin and mithramycin

668

Discovery of the tungsten isotopes

669

Discovery of the vanadium isotopes

670

Discovery of the Yamato Meteorites in 1969

671

Discovery of thiadiazoles as a novel structural class of potent and selective PDE7 inhibitors. Part 1: Design, synthesis and structure–activity relationship studies

672

Discovery of thiadiazoles as a novel structural class of potent and selective PDE7 inhibitors. Part 2: Metabolism-directed optimization studies towards orally bioavailable derivatives

673

Discovery of thieno[2,3-c]pyridines as potent COT inhibitors

674

Discovery of thienopyridines as Src-family selective Lck inhibitors

675

Discovery of Thioazepinone Ligands for Src SH2: From Non-specific to Specific Binding

676

Discovery of thiochroman and chroman derivatives as pure antiestrogens and their structure–activity relationship Original Research Article

677

Discovery of thiochroman derivatives bearing a carboxy-containing side chain as orally active pure antiestrogens

678

Discovery of thiophene-2-carboxylic acids as potent inhibitors of HCV NS5B polymerase and HCV subgenomic RNA replication. Part 1: Sulfonamides

679

Discovery of thiophene-2-carboxylic acids as potent inhibitors of HCV NS5B polymerase and HCV subgenomic RNA replication. Part 2: Tertiary amides

680

Discovery of thiophene-2-carboxylic acids as potent inhibitors of HCV NS5B polymerase and HCV subgenomic RNA replication. Part 2: Tertiary amides

681

Discovery of three new mordellids (Coleoptera, Tenebrionoidea) from the Yixian Formation of western Liaoning, China

682

Discovery of TNF Inhibitors from a DNA-Encoded Chemical Library based on Diels-Alder Cycloaddition Original Research Article

683

Discovery of trans-3,4′-bispyridinylethylenes as potent and novel inhibitors of protein kinase B (PKB/Akt) for the treatment of cancer: Synthesis and biological evaluation

684

Discovery of trans-N-[1-(2-fluorophenyl)-3-pyrazolyl]-3-oxospiro[6-azaisobenzofuran-1(3H),1′-cyclohexane]-4′-carboxamide, a potent and orally active neuropeptide Y Y5 receptor antagonist Original Research Article

685

Discovery of triazolinone non-nucleoside inhibitors of HIV reverse transcriptase

686

Discovery of trypanocidal thiosemicarbazone inhibitors of rhodesain and TbcatB

687

Discovery of two northern hemisphere Armillaria species on Proteaceae in South Africa

688

Discovery of two ophiolite complexes of different ages in the Khoy area (NW Iran)

689

Discovery of two potential DAZL gene markers for sperm quality in boars by population association studies

690

DISCOVERY OF ULTRACOMPACT DWARF GALAXIES IN THE VIRGO CLUSTER

691

Discovery of underground argon with low level of radioactive 39Ar and possible applications to WIMP dark matter detectors

692

Discovery of underground argon with low level of radioactive 39Ar and possible applications to WIMP dark matter detectors

693

Discovery of Unertan Syndrome and Reverse Evolution: As An “Aha!” Experience

694

Discovery of uracil-based histone deacetylase inhibitors able to reduce acquired antifungal resistance and trailing growth in Candida albicans

695

Discovery of Wall Teichoic Acid Inhibitors as Potential Anti-MRSA β-Lactam Combination Agents Original Research Article

696

Discovery of whitlockite in mantle xenoliths: Inferences for water- and halogen-poor fluids and trace element residence in the terrestrial upper mantle

697

Discovery of Widespread GTP-Binding Motifs in Genomic DNA and RNA Original Research Article

698

Discovery of X-Ray Burst Oscillations from a Neutron Star X-Ray Transient in the Globular Cluster NGC 6440

699

Discovery of X-Ray Quasi-Periodic Oscillations from an Ultraluminous X-Ray Source in M82: Evidence against Beaming

700

Discovery of yttrium, zirconium, niobium, technetium, and ruthenium isotopes

701

Discovery of zinc, selenium, bromine, and neodymium isotopes

702

Discovery of zoniporide: A potent and selective sodium–hydrogen exchanger type 1 (NHE-1) inhibitor with high aqueous solubility

703

Discovery of β-benzamido hydroxamic acids as potent, selective, and orally bioavailable TACE inhibitors

704

Discovery of γ-secretase inhibitors efficacious in a transgenic animal model of Alzheimer’s disease

705

Discovery potential for doubly charged Higgs bosons in e+e− collisions at LEP

706

Discovery potential for new physics in view of the RHIC-Spin upgrade

707

Discovery potential of new boson image in the Minimal Higgsless model at LHC Original Research Article

708

Discovery prospects for a supernova signature of biogenic origin

709

Discovery stage pharmacokinetics using dried blood spots

710

Discovery, characterization and SAR of gambogic acid as a potent apoptosis inducer by a HTS assay Original Research Article

711

Discovery, In Vivo Activity, and Mechanism of Action of a Small-Molecule p53 Activator

712

Discovery, SAR and X-ray structure of 1H-benzimidazole-5-carboxylic acid cyclohexyl-methyl-amides as inhibitors of inducible T-cell kinase (Itk)

713

Discovery, SAR, and X-ray structure of novel biaryl-based dipeptidyl peptidase IV inhibitors

714

Discovery, SAR, synthesis, pharmacokinetic and biochemical characterization of A-192411: A novel fungicidal lipopeptide-(I)

715

Discovery, structure and biological activities of cyclotides

716

Discovery, structure and HIV-1 integrase inhibitory activities of integracins, novel dimeric alkyl aromatics from Cytonaema sp.

717

Discovery, structure–activity relationship study, and oral analgesic efficacy of cyproheptadine derivatives possessing N-type calcium channel inhibitory activity Original Research Article

718

Discovery, synthesis and biological evaluation of isoquinolones as novel and highly selective JNK inhibitors (1) Original Research Article

719

Discovery, synthesis and biological evaluation of isoquinolones as novel and highly selective JNK inhibitors (2) Original Research Article

720

Discovery, synthesis and biological evaluation of novel glucokinase activators

721

Discovery, synthesis, and structure–activity studies of tetrazole based growth hormone secretagogues

722

Discovery, total synthesis, HRV 3C-protease inhibitory activity, and structure–activity relationships of 2-methoxystypandrone and its analogues

723

Discovery, visualization and performance analysis of enterprise workflow

724

Discrepancies among clinical, histological and immunological findings in IgA pemphigus: a case report and literature survey

725

Discrepancies Between Biopsy Gleason Score and Radical Prostatectomy Specimen Gleason Score: An Iranian Experience

726

Discrepancies between catheter and Doppler estimates of valve effective orifice area can be predicted from the pressure recovery phenomenon: practical implications with regard to quantification of aortic stenosis severity

727

Discrepancies between classic anatomy and modern gynecologic surgery on pelvic connective tissue structure: Harmonization of those concepts by collaborative cadaver dissection

728

Discrepancies between desired and perceived measures of performance of IS professionals: Views of the IS professionals themselves and the users

729

Discrepancies between desired and perceived measures of performance of IS professionals: Views of the IS professionals themselves and the users

730

Discrepancies between echocardiographic measurements of left ventricular mass in a healthy adult population

731

Discrepancies between ecological and individual data on fruit and vegetable consumption in fifteen countries

732

Discrepancies between ergosterol and the phospholipid fatty acid 18:2ω6,9 as biomarkers for fungi in boreal forest soils

733

Discrepancies between ergosterol and the phospholipid fatty acid 18:2ω6,9 as biomarkers for fungi in boreal forest soils

734

Discrepancies Between Free Vibration of FML and Composite Cylindrical Shells Reinforced by CNTs

735

Discrepancies between metric dimension and partition dimension of a connected graph Original Research Article

736

Discrepancies between microscopic (TEM) and macroscopic (texture) observations in high temperature deformation of FeAl and Fe3Al-based alloys

737

Discrepancies between microscopic (TEM) and macroscopic (texture) observations in high temperature deformation of FeAl and Fe3Al-based alloys

738

Discrepancies between N-Acetyl Cysteine Prescription based on Patient’s History and Plasma Acetaminophen Level

739

Discrepancies Between Normative and Descriptive Models of Decision Making and the Understanding/Acceptance Principle,

740

Discrepancies between roughness measurements obtained with phase-shifting and white-light interferometry

741

Discrepancies between Self- and Clinical Staff Members’ Perception of Cognitive Functioning among Patients with Schizophrenia Undergoing Long-Term Hospitalization

742

Discrepancies between self and observer ratings of depression: The relationship to demographic, clinical and personality variables

743

Discrepancies between self-report and objective measures for stimulant drug use in HIV: Cognitive, medication adherence and psychological correlates

744

Discrepancies between self-reported and observed physical function in the elderly: the influence of response shift and other factors

745

Discrepancies between self-reported years of education and estimated reading level among elderly community-dwelling African-Americans: Analysis of the MOAANS data

746

Discrepancies Between Sizer and Valve Dimensions: Implications for Small Aortic Root

747

Discrepancies between the Speech of Male and Female in Lecturing: Language Management in Focus

748

Discrepancies in brine density databases at geothermal conditions

749

Discrepancies in Cancer Mortality Estimates

750

Discrepancies in diagnosing Osteopenia and Osteoporosis with bone densitometry at spine and femoral neck

751

Discrepancies in earthquake location between ISC and other agencies

752

Discrepancies in Evaluating Farm Management Routines as Risk Factors of Raw Milk and Udder Hygiene in Selected Dairy Farms of Fars Province, Iran

753

Discrepancies in initial death certificate diagnoses in sudden unexpected out-of-hospital deaths: the role of cardiovascular autopsy

754

Discrepancies in interpretation of ED body computed tomographic scans by radiology residents

755

Discrepancies in interpretation of night-time emergency computed tomography scans by radiology residents

756

Discrepancies in mental functioning relative to word knowledge on the Speed and Capacity of Language-Processing Test

757

Discrepancies in military middle-school adolescentsʹ and parentsʹ perceptions of family functioning, social support, anger frequency, and concerns

758

Discrepancies in pelvic anatomy

759

Discrepancies in performance status scores as determined by cancer patients and oncologists: are they influenced by depression?

760

Discrepancies in SART (Society for Assisted Reproductive Technology) reporting

761

Discrepancies in the Monte Carlo simulations of propagation of ultra-high energy cosmic-ray photons in the geomagnetic field

762

Discrepancies in the morphology and physical properties of amorphous and crystalline sprayed lanthanum nickel oxide films Original Research Article

763

Discrepancy and signed domination in graphs and hypergraphs

764

Discrepancy behaviour in the non-asymptotic regime Original Research Article

765

Discrepancy between actual and ideal body images: Impact on eating and exercise behaviors

766

Discrepancy between Actual and Theoretical Anterior Chamber Depth in Patients with Morcher Posterior Chamber Intraocular Lens

767

Discrepancy between Admission and Discharge Diagnoses in Central Serbia: Analysis by the Groups of International Classification of Diseases, 10th Revision

768

Discrepancy Between Admission Diagnosis and Discharge Diagnosis in Cardiovascular Diseases: An Analysis Based On the Groups of International Classification Disease, 10th Revision

769

Discrepancy between auditory brainstem responses, auditory steady-state responses, and auditory behavior in two patients with Pelizaeus-Merzbacher disease

770

Discrepancy between clinical staging through bimanual palpation and pathological staging after cystectomy

771

Discrepancy between fatigue and dwell-fatigue behavior of near alpha titanium alloys simulated by cellular automata

772

Discrepancy Between Intraoperative Transesophageal Echocardiography and Postoperative Transthoracic Echocardiography in Assessing Congenital Valve Surgery

773

Discrepancy between photoluminescence and photoresponse intensities in n-InAs/GaAs and InAs/n-GaAs quantum-dot heterostructures

774

Discrepancy between second and first opinion in surgical oncological patients

775

Discrepancy between serum leptin values and total body fat in response to the oral growth hormone secretagogue MK-677

776

Discrepancy between Sr isotope and biostratigraphic datings of the upper middle and upper Miocene successions (Eastern North Sea Basin, Denmark)

777

Discrepancy between subjective and objective ratings for negative symptoms

778

Discrepancy between the theory and polarization observations in the 530.3 nm solar coronal line Original Research Article

779

Discrepancy between theory and real computation on the stability of some finite element schemes

780

Discrepancy detection and developmental changes in attentional engagement in infancy

781

Discrepancy estimates based on Haar functions Original Research Article

782

Discrepancy for uniform design of experiments with mixtures

783

Discrepancy in ABO Blood Grouping in a Blood Donor: A Case Report

784

Discrepancy in different numbers of colors Original Research Article

785

Discrepancy in generalized arithmetic progressions

786

Discrepancy in pd breakup reaction at image Original Research Article

787

Discrepancy in regression estimates between log-normal and gamma: some case studies

788

Discrepancy in Screening Performances of Different Rapid Test Kits for SARS-CoV-2; a Letter to Editor

789

Discrepancy in serum carcinoembryonic antigen levels by measuring kits

790

Discrepancy in serum carcinoembryonic antigen levels by measuring kits: Reply

791

Discrepancy in the preferences of place of death between terminally ill cancer patients and their primary family caregivers in Taiwan

792

Discrepancy measures for selecting optimal combination of parameter values in object-based image analysis

793

Discrepancy of (centered) arithmetic progressions in

794

Discrepancy of Arithmetic Progressions in Higher Dimensions Original Research Article

795

Discrepancy of Centered Arithmetic Progressions in (Extended Abstract)

796

Discrepancy of computed tomographic image between lung and mediastinal windows as a prognostic implication in small lung adenocarcinoma

797

Discrepancy of Graham Greene

798

Discrepancy of response of hPTH administration and its withdrawal between trabecular and cortical bone sites in ovx rats

799

Discrepancy of structural stability against temperature between metallic liquids and their glasses

800

Discrepancy of Sums of Arithmetic Progressions

801

Discrepancy of Sums of two Arithmetic Progressions

802

Discrepancy of the spectral data between adunctin E and the synthetic one

803

Discrepancy of Weyl Sequences (nα) Perturbed by Rationally Periodic Functions

804

Discrepancy principle for DSM II

805

Discrepancy principle for the dynamical systems method

806

Discrepancy rates of preliminary and final reports for after-hours pediatric teleradiology interpretations

807

Discrepancy searchfortheflexiblejobshopschedulingproblem

808

Discrepancy with respect to convex polygons

809

Discrepancy-based error estimates for Quasi-Monte Carlo I. General formalism Original Research Article

810

Discrepancy-based error estimates for Quasi-Monte Carlo II. Results in one dimension Original Research Article

811

Discrepancy-based error estimates for Quasi-Monte Carlo III. Error distributions and central limits Original Research Article

812

Discrepant analysis and screening for Chlamydia trachomatis

813

Discrepant analysis and screening for Chlamydia trachomatis

814

Discrepant analysis and screening for Chlamydia trachomatis

815

Discrepant analysis and screening for Chlamydia trachomatis

816

Discrepant analysis and screening for Chlamydia trachomatis

817

Discrepant analysis and screening for Chlamydia trachomatis

818

Discrepant analysis—or behaviour?

819

Discrepant and congruent high self-esteem: Behavioral self-handicapping as a preemptive defensive strategy

820

Discrepant Cytogenetic and Fluorescence In Situ Hybridization Results in a 26-Year-Old Male with Early T-Cell Acute Lymphocytic Leukemia

821

Discrepant epidemiological patterns between classical and atypical scrapie in sheep flocks under French TSE control measures

822

Discrepant fluency increases subjective truth

823

Discrepant illness perceptions, affect and expressed emotion in people with psychosis and their carers

824

Discrepant impacts of land use and land cover on urban heat islands: A case study of Shanghai, China

825

Discrepin, a new peptide of the sub-family α-ktx15, isolated from the scorpion Tityus discrepans irreversibly blocks K+-channels (IA currents) of cerebellum granular cells

826

Discrete (carbon free) chelate rings derived from sodium tetraphenylimidodiphosphinochalcogenides (S and Se) and 15-crown-5

827

Discrete 3D model as complimentary numerical testing for anisotropic damage

828

Discrete abstractions for robot motion planning and control in polygonal environments

829

Discrete accidental symmetry for a particle in a constant magnetic field on a torus Original Research Article

830

Discrete acoustic emission waves during stick–slip friction between steel samples

831

Discrete actions on nilpotent Lie groups and negatively curved spaces

832

Discrete active models and applications

833

Discrete Adaptive Sliding Mode Control of a State-Space System with a Bounded Disturbance

834

Discrete adaptive sliding-mode control of a class of stochastic systems

835

Discrete adaptive sliding-mode tracking controller

836

Discrete ADM: A tool for solving a class of classic and fractional difference problems

837

Discrete Adomian Decomposition solution of Nonlinear Fredholm Integral Equation

838

Discrete algebraic estimator design for non-linear Liouvillian systems with sampled output: Application to a class of stirred bioreactor

839

Discrete analog electronics for high-resistivity silicon detectors used for X-ray and γ-ray spectroscopy in whole-body monitoring

840

Discrete analog electronics for high-resistivity silicon detectors used for X-ray and γ-ray spectroscopy in whole-body monitoring

841

Discrete analogue of Fučik spectrum of the Laplacian

842

Discrete anchoring: Bulk-substrate coupling in lattice models

843

Discrete and 1D coordination polymeric chloro-bridged copper(II) dimers exhibiting ferro- and antiferromagnetic exchange coupling: Magneto-structural correlations and non-covalent interactions

844

Discrete and continuous conceptualizations of science: Implications for knowledge domain visualization

845

Discrete and continuous deformation during nanoindentation of thin films Original Research Article

846

Discrete and continuous dynamical systems

847

Discrete and continuous expectation formulae for level-crossings, upcrossings and excursions of ellipsoidal processes

848

Discrete and continuous joint coupling relationships in uninjured recreational runners

849

Discrete and continuous linearizable equations

850

Discrete and Continuous Mathematical Models of DNA Branch Migration

851

Discrete and continuous maximum principles for parabolic and elliptic operators

852

Discrete and continuous models for in plane loaded random elastic brickwork

853

Discrete and continuous models of the dynamics of pelagic fish: Application to the capelin Original Research Article

854

Discrete and continuous nonlinear models for the vibrating rod

855

Discrete and continuous reproductive tactics in a hermaphroditic society

856

Discrete and continuous state population models in a noisy world

857

Discrete and continuous time cointegration

858

Discrete and continuous time simulations of spatial ecological processes predict different final population sizes and interspecific competition outcomes

859

Discrete and continuous time simulations of spatial ecological processes predict different final population sizes and interspecific competition outcomes

860

Discrete- and continuous-time local cosine bases with multiple overlapping

861

Discrete and continuum modelling of excavator bucket filling

862

Discrete and cyclical movements: unified dynamics or separate control?

863

Discrete and dynamic versus continuous and static loading policy for a multi-compartment vehicle

864

Discrete and infinite metal–organometallic coordination networks consisting of europium(III) nodes and quinone π-complexes as spacers

865

Discrete and oscillatory matrix models in Chern–Simons theory Original Research Article

866

Discrete anomalies and the null cone of SYM theories

867

Discrete anomaly matching Original Research Article

868

Discrete approach for flow field designs of parallel channel configurations in fuel cells

869

Discrete Approach to PWL Analog Modeling in VHDL Environment

870

Discrete approach to study fracture energy absorption under dynamic loading

871

Discrete approximation by variational vector splines for noisy data Original Research Article

872

Discrete Approximation of Unbounded Operators and Approximation of their Spectra Original Research Article

873

Discrete approximation to the global spectrum of the tangent operator for flow past a circular cylinder Original Research Article

874

Discrete approximationheuristicsforthecapacitatedcontinuouslocation–allocation problemwithprobabilisticcustomerlocations

875

Discrete approximations of solutions and derivatives for a singularly perturbed parabolic convection–diffusion equation

876

Discrete approximations of the Föppl–Von Kármán shell model: From coarse to more refined models

877

Discrete Approximations to Continuum Optimal Flow Problems

878

Discrete approximations to optimization of neutral functional differential inclusions

879

Discrete approximations to real-valued leaf sequencing problems in radiation therapy Original Research Article

880

Discrete approximations, relaxation, and optimization of one-sided Lipschitzian differential inclusions in Hilbert spaces

881

Discrete artificial boundary conditions for nonlinear Schrِdinger equations

882

Discrete artificial boundary conditions for transient scalar wave propagation in a 2D unbounded layered media Original Research Article

883

Discrete bands of petroleum hydrocarbons and molecular organic markers identified within massive coral skeletons

884

Discrete bandwidth allocation considering fairness and transmission load in multicast networks

885

Discrete bandwidth visual feedback increases structure of output as compared to continuous visual feedback in isometric force control tasks

886

Discrete Bargmann and Neumann systems and finite-dimensional integrable systems

887

Discrete behavior of Seshadri constants on surfaces

888

Discrete bilevel programming: Application to a natural gas cash-out problem

889

Discrete bilinear stochastic systems with time-varying delay: Stability analysis and control synthesis

890

Discrete biorthogonal wavelet transforms as block circulant matrices Original Research Article

891

Discrete bipolar universal integrals

892

Discrete bond-weighted random scission of linear polymers

893

Discrete boundary conditions for elasticity problems with singularities Original Research Article

894

Discrete boundary conditions for problems with interface Original Research Article

895

Discrete branching processes, QCD and multiparticle distributions

896

Discrete breathers — Advances in theory and applications

897

Discrete breathers — Advances in theory and applications

898

Discrete breathers and nonlinear normal modes in monoatomic chains

899

Discrete breathers in aperiodic diatomic FPU lattices with long range order

900

Discrete breathers in Josephson ladders

901

Discrete breathers in nonlinear Schrِdinger hypercubic lattices with arbitrary power nonlinearity

902

Discrete breathers in thermal equilibrium: distributions and energy gaps

903

Discrete breathers in transient processes and thermal equilibrium

904

Discrete breathers in two-dimensional anisotropic nonlinear Schrِdinger lattices

905

Discrete breathers in two-dimensional nonlinear lattices

906

Discrete breathers: classical and quantum

907

Discrete Breathers: Localization and transfer of energy in discrete Hamiltonian nonlinear systems

908

Discrete buckling model for corrugated beam

909

Discrete calculus methods for diffusion

910

Discrete Calderon’s projections on parallelepipeds and their application to computing exterior magnetic fields for FRC plasmas

911

Discrete camera calibration from pixel streams

912

Discrete capacity and flow assignment algorithms with performance guarantee

913

Discrete cellular entry points discovered in neuronal membrane

914

Discrete chaos induced by heteroclinic cycles connecting repellers in Banach spaces Original Research Article

915

Discrete characterization of cohesion in gas–solid flows

916

Discrete characterization tools for cohesive granular material

917

Discrete charge dielectric model of electrostatic energy

918

Discrete chirp-Fourier transform and its application to chirp rate estimation

919

Discrete choice modeling with nonstationary panels applied to exchange rate regime choice

920

Discrete choice models and optimal two-part tariffs in the presence of externalities: optimal taxation of cars

921

Discrete choice models of pedestrian walking behavior

922

Discrete choice models with capacity constraints: An empirical analysis of the housing market of the greater Paris region

923

Discrete choice models with latent choice sets

924

DISCRETE CHOICE MODELS WITH MULTIPLE UNOBSERVED CHOICE CHARACTERISTICS∗

925

Discrete choice survey experiments: A comparison using flexible methods

926

Discrete Choice under Preference Uncertainty: An Improved Structural Model for Contingent Valuation

927

Discrete choice with an oddball alternative

928

Discrete Choquet integral and some of its symmetric extensions

929

Discrete clay diagenesis in a very low-permeable sequence constrained by an isotopic (K-Ar and Rb-Sr) study

930

Discrete cloud activity in Saturn’s equator during 1995, 1996 and 1997

931

Discrete Clutch Sizes, Local Mate Competition, and the Evolution of Precise Sex Allocation

932

Discrete Cocompact Subgroups of the Four-Dimensional Nilpotent Connected Lie Group and Their Group C∗-Algebras1

933

Discrete cohesive zone model for mixed-mode fracture using finite element analysis

934

Discrete collocation method for Volterra type weakly singular integral equations with logarithmic kernels

935

Discrete combinatorial geometry

936

Discrete competing risk model with application to modeling bus-motor failure data

937

Discrete competing risk model with application to modeling bus-motor failure data

938

Discrete computer simulation of bedrooms

939

Discrete Concavity and Zeros of Polynomials

940

Discrete conjugate boundary value problems Original Research Article

941

Discrete conservation and coupling strategies in nonlinear aeroelasticity Original Research Article

942

Discrete conservation laws and the convergence of long time simulations of the mkdv equation

943

Discrete constant-velocity-equivalent multirate models for target tracking

944

Discrete contact mechanics of a fibrillar surface with backing layer interactions

945

Discrete continuation method for boundary value problems on bounded sets in Banach spaces

946

Discrete control for a computer hard disk by using a fractional order hold device

947

Discrete control of unified power flow controller for stability improvement

948

Discrete conventional signalling of a continuous variable

949

Discrete conversion of gamma rays in 229Th and in highly ionized 125TeQ ions

950

Discrete convexity and unimodularity—I

951

Discrete Coons patches Original Research Article

952

Discrete Copulas

953

Discrete cosine transform LSQR methods for multidimensional ill-posed problems

954

Discrete Countercurrent Contacting; An Experimental Method for Developing Continuous Countercurrent Reactors

955

Discrete crack analysis of concrete gravity dams based on the known inertia force field of linear response analysis

956

Discrete crack modelling of ductile fracture driven by non-local softening plasticity

957

Discrete crack path prediction by an adaptive cohesive crack model

958

Discrete cubic water cluster: An unusual building block of 3D supramolecular network

959

Discrete Curves in and the Toda Lattice

960

Discrete damage zone model for fracture initiation and propagation

961

Discrete data assimilation in the Lorenz and 2D Navier–Stokes equations

962

Discrete deformations in Type I vacua

963

Discrete degradation modeling using generalized mixed effect model

964

Discrete Derivatives of Sequences

965

Discrete Design Optimization of Small Open Type Dry Transformers

966

Discrete deterministic and stochastic blending problems with two quality characteristics: aluminum blending

967

Discrete deterministic and stochastic blending problems with two quality characteristics: aluminum blending

968

Discrete devaluations and multiple equilibria in a first generation model of currency crises

969

Discrete devaluations and multiple equilibria in a first generation model of currency crises

970

Discrete Dichotomies and Bifurcations from Critical Homoclinic Orbits

971

Discrete Differential Geometry

972

Discrete dihedral-angle modulation in porphyrin wheels adsorbed on Cu(1 0 0) observed by scanning tunneling microscopy

973

Discrete dipole approximation simulations of scattering by particles with hierarchical structure

974

Discrete direct and adjoint sensitivity analysis for arbitrary Mach number flows

975

Discrete Dirichlet-to-Neumann maps for unbounded domains Original Research Article

976

Discrete dislocation analyses of circular nanoindentation and its size dependence in polycrystals Original Research Article

977

Discrete dislocation analysis of the wedge indentation of polycrystals Original Research Article

978

Discrete dislocation and continuum descriptions of plastic flow

979

Discrete dislocation and continuum descriptions of plastic flow

980

Discrete dislocation density modelling of single phase FCC polycrystal aggregates Original Research Article

981

Discrete dislocation dynamics analysis of the effect of lattice orientation on void growth in single crystals

982

Discrete dislocation dynamics by an O(N) algorithm

983

Discrete dislocation dynamics modelling of mechanical deformation of nickel-based single crystal superalloys

984

Discrete dislocation dynamics modelling of microvoid growth and its intrinsic mechanism in single crystals Original Research Article

985

Discrete dislocation dynamics simulation of cutting of γ′ precipitate and interfacial dislocation network in Ni-based superalloys

986

Discrete dislocation dynamics simulations of plasticity at small scales Original Research Article

987

Discrete dislocation dynamics simulations of surface induced size effects in plasticity

988

Discrete dislocation dynamics simulations to interpret plasticity size and surface effects in freestanding FCC thin films

989

Discrete dislocation dynamics study on interaction between prismatic dislocation loop and interfacial network dislocations

990

Discrete dislocation dynamics: an important recent break-through in the modelling of dislocation collective behaviour

991

Discrete dislocation modeling in three-dimensional confined volumes

992

Discrete dislocation modeling in three-dimensional confined volumes

993

Discrete dislocation modeling of fatigue crack propagation Original Research Article

994

Discrete dislocation modeling of fracture in plastically anisotropic metals

995

Discrete dislocation modelling of near threshold fatigue crack propagation

996

Discrete dislocation modelling of submicron indentation

997

Discrete dislocation plasticity analysis of single crystalline thin beam under combined cyclic tension and bending Original Research Article

998

Discrete dislocation plasticity analysis of single slip tension

999

Discrete dislocation plasticity analysis of static friction Original Research Article

1000

Discrete dislocation plasticity analysis of the grain size dependence of the flow strength of polycrystals